APC
APC regulator of Wnt signaling pathway
Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]
Known Variants8,703 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs182505835 | 5:112,032,684 | C/T | — | likely benign |
| rs115535112 | 5:112,042,873 | C/T | — | likely benign |
| rs73216228 | 5:112,042,929 | G/A | — | benign |
| rs114830579 | 5:112,042,951 | C/G | — | likely benign |
| rs116505416 | 5:112,042,999 | A/G | — | benign |
| rs185951958 | 5:112,043,009 | C/T | — | likely benign |
| rs1214142280 | 5:112,043,011 | G/A | — | uncertain significance |
| rs1750548089 | 5:112,043,012 | C/T | — | uncertain significance |
| rs2149627907 | 5:112,043,013 | A/G | — | uncertain significance |
| rs2149627912 | 5:112,043,014 | G/C | — | uncertain significance |
| rs931897682 | 5:112,043,015 | C/G | — | uncertain significance |
| rs2149627922 | 5:112,043,017 | C/A | — | uncertain significance |
| rs2531729934 | 5:112,043,018 | A/C | — | uncertain significance |
| rs2531729947 | 5:112,043,019 | A/G | — | uncertain significance |
| rs1750548254 | 5:112,043,020 | T/C | — | uncertain significance |
| rs1750548351 | 5:112,043,022 | C/G | — | uncertain significance |
| rs2149627939 | 5:112,043,023 | A/T | — | uncertain significance |
| rs1750548429 | 5:112,043,024 | G/C | — | uncertain significance |
| rs2531730040 | 5:112,043,025 | A/T | — | uncertain significance |
| rs1750548760 | 5:112,043,026 | G/A | — | uncertain significance |
| rs1461935725 | 5:112,043,029 | G/A | — | uncertain significance |
| rs1554060090 | 5:112,043,030 | G/T | — | uncertain significance |
| rs1554060091 | 5:112,043,031 | C/T | — | uncertain significance |
| rs1554060092 | 5:112,043,033 | A/G | — | uncertain significance |
| rs370035028 | 5:112,043,034 | G/A | — | uncertain significance |
| rs1750549577 | 5:112,043,035 | T/C | — | uncertain significance |
| rs1554060095 | 5:112,043,036 | A/T | — | uncertain significance |
| rs1469439532 | 5:112,043,037 | A/G | — | uncertain significance |
| rs1554060097 | 5:112,043,038 | G/C | — | uncertain significance |
| rs1580995288 | 5:112,043,039 | T/C | — | uncertain significance |
| rs1050218356 | 5:112,043,040 | G/C | — | uncertain significance |
| rs2149628038 | 5:112,043,041 | C/G | — | uncertain significance |
| rs1750550286 | 5:112,043,042 | T/C | — | uncertain significance |
| rs1232455560 | 5:112,043,043 | G/A | — | uncertain significance |
| rs2531730437 | 5:112,043,044 | C/A | — | uncertain significance |
| rs887610659 | 5:112,043,045 | A/G | — | uncertain significance |
| rs1750550706 | 5:112,043,046 | A/G | — | uncertain significance |
| rs1750550790 | 5:112,043,047 | C/T | — | uncertain significance |
| rs1554060105 | 5:112,043,048 | T/C | — | uncertain significance |
| rs1750550976 | 5:112,043,049 | G/T | — | uncertain significance |
| rs2531730579 | 5:112,043,050 | A/G | — | uncertain significance |
| rs545524187 | 5:112,043,051 | G/C | — | uncertain significance |
| rs1750551409 | 5:112,043,052 | A/G | — | uncertain significance |
| rs2149628125 | 5:112,043,053 | C/T | — | uncertain significance |
| rs1580995308 | 5:112,043,054 | T/A | — | uncertain significance |
| rs1554060110 | 5:112,043,055 | C/T | — | uncertain significance |
| rs560366894 | 5:112,043,056 | G/T | — | uncertain significance |
| rs2149628157 | 5:112,043,057 | G/A | — | uncertain significance |
| rs1750551783 | 5:112,043,058 | C/A | — | uncertain significance |
| rs113077479 | 5:112,043,059 | T/C | — | uncertain significance |
| rs1580995331 | 5:112,043,060 | G/A | — | uncertain significance |
| rs2149628192 | 5:112,043,061 | C/T | — | uncertain significance |
| rs1554060114 | 5:112,043,062 | C/T | — | uncertain significance |
| rs929883108 | 5:112,043,063 | T/C | — | uncertain significance |
| rs1046974767 | 5:112,043,064 | A/G | — | uncertain significance |
| rs1320184514 | 5:112,043,065 | G/A | — | uncertain significance |
| rs1232017569 | 5:112,043,066 | G/A | — | uncertain significance |
| rs1273083857 | 5:112,043,067 | C/T | — | uncertain significance |
| rs1554060123 | 5:112,043,068 | A/G | — | uncertain significance |
| rs2149628251 | 5:112,043,070 | C/T | — | uncertain significance |
| rs527914616 | 5:112,043,071 | A/C | — | uncertain significance |
| rs13180781 | 5:112,043,072 | G/A | — | uncertain significance |
| rs1218378018 | 5:112,043,073 | T/G | — | uncertain significance |
| rs1005173527 | 5:112,043,074 | G/A | — | uncertain significance |
| rs1243549213 | 5:112,043,075 | G/C | — | uncertain significance |
| rs2149628304 | 5:112,043,076 | C/G | — | uncertain significance |
| rs2149628308 | 5:112,043,078 | C/G | — | uncertain significance |
| rs2149628316 | 5:112,043,079 | A/T | — | uncertain significance |
| rs1484697641 | 5:112,043,080 | C/G | — | uncertain significance |
| rs1554060128 | 5:112,043,081 | G/A | — | uncertain significance |
| rs1192399402 | 5:112,043,082 | G/A | — | uncertain significance |
| rs1351477360 | 5:112,043,083 | G/C | — | uncertain significance |
| rs1257642100 | 5:112,043,086 | A/G | — | uncertain significance |
| rs1750554761 | 5:112,043,087 | G/C | — | uncertain significance |
| rs1750554840 | 5:112,043,088 | A/G | — | uncertain significance |
| rs994601309 | 5:112,043,090 | C/G | — | uncertain significance |
| rs571137741 | 5:112,043,091 | A/G | — | uncertain significance |
| rs1750555075 | 5:112,043,092 | G/C | — | uncertain significance |
| rs1750555186 | 5:112,043,093 | C/T | — | uncertain significance |
| rs1554060134 | 5:112,043,094 | G/T | — | uncertain significance |
| rs1393524919 | 5:112,043,095 | A/C | — | uncertain significance |
| rs1580995476 | 5:112,043,096 | A/G | — | uncertain significance |
| rs1750555732 | 5:112,043,097 | G/A | — | uncertain significance |
| rs1554060135 | 5:112,043,098 | C/G | — | uncertain significance |
| rs1750555884 | 5:112,043,099 | A/G | — | uncertain significance |
| rs1035047381 | 5:112,043,100 | G/C | — | uncertain significance |
| rs1248905809 | 5:112,043,101 | T/C | — | uncertain significance |
| rs1580995493 | 5:112,043,102 | G/A | — | uncertain significance |
| rs1750556409 | 5:112,043,103 | C/A | — | uncertain significance |
| rs960491839 | 5:112,043,104 | C/A | — | uncertain significance |
| rs989021062 | 5:112,043,105 | C/G | — | uncertain significance |
| rs1020543876 | 5:112,043,106 | G/C | — | uncertain significance |
| rs896715004 | 5:112,043,107 | G/A | — | uncertain significance |
| rs1268337460 | 5:112,043,108 | C/T | — | uncertain significance |
| rs1012461653 | 5:112,043,109 | A/T | — | uncertain significance |
| rs1345543059 | 5:112,043,110 | A/T | — | uncertain significance |
| rs1432662523 | 5:112,043,111 | G/A | — | uncertain significance |
| rs1580995550 | 5:112,043,112 | C/T | — | uncertain significance |
| rs1373788988 | 5:112,043,113 | G/T | — | uncertain significance |
| rs1173265814 | 5:112,043,114 | G/C | — | uncertain significance |
Showing 100 of 8,703 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.