FOXO3

forkhead box O3

Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Known Variants62 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1463974336	6:108,882,425	C/T	—	uncertain significance
rs1396187319	6:108,882,427	G/T	—	uncertain significance
rs1191293561	6:108,882,443	T/G	—	uncertain significance
rs909124051	6:108,882,490	C/T	—	uncertain significance
rs540196548	6:108,882,563	C/T	—	uncertain significance
rs771834327	6:108,882,631	G/A	—	uncertain significance
rs1415832829	6:108,882,674	T/G	—	uncertain significance
rs1228590271	6:108,882,680	C/G	—	uncertain significance
rs1344931063	6:108,882,746	C/T	—	uncertain significance
rs944210246	6:108,882,767	T/A	—	uncertain significance
rs767626656	6:108,882,824	C/T	—	uncertain significance
rs111556510	6:108,882,830	C/T	—	benign
rs756842922	6:108,882,839	G/T	—	uncertain significance
rs778623754	6:108,882,842	C/G	—	uncertain significance
rs749898404	6:108,882,843	C/T	—	likely benign
rs1182679423	6:108,882,844	G/A	—	uncertain significance
rs150320900	6:108,882,915	C/T	—	benign
rs1554209779	6:108,882,994	A/T	—	other
rs1536057	6:108,885,623	C/T	regulatory region variant	—
rs2253310	6:108,888,593	C/G	intron variant	—
rs2764265	6:108,894,438	C/A	—	—
rs2490272	6:108,895,386	C/G	—	—
rs2802288	6:108,896,215	A/T	—	—
rs2802290	6:108,905,680	G/A	intron variant	—
rs2802292	6:108,908,518	G/T	intron variant	benign
rs13220810	6:108,913,201	T/C	regulatory region variant	—
rs9480865	6:108,916,573	T/C	intron variant	—
rs2802295	6:108,926,496	A/G	intron variant	—
rs7753734	6:108,927,841	C/T	regulatory region variant	—
rs7754626	6:108,928,171	G/A	intron variant	—
rs2764264	6:108,934,461	C/T	downstream gene variant	—
rs13217795	6:108,974,098	C/T	intron variant	—
rs9400239	6:108,977,663	T/G	—	—
rs12212067	6:108,981,196	T/G	intron variant	—
rs1554218944	6:108,984,735	G/A	—	other
rs61756661	6:108,984,783	G/A	—	benign
rs771516569	6:108,984,818	C/T	—	uncertain significance
rs1245687963	6:108,984,950	C/T	—	uncertain significance
rs1778954287	6:108,985,027	A/G	—	uncertain significance
rs145259784	6:108,985,057	G/A	—	benign
rs755424488	6:108,985,097	T/G	—	uncertain significance
rs374860833	6:108,985,221	G/A	—	benign
rs1321459699	6:108,985,259	T/C	—	uncertain significance
rs761888480	6:108,985,262	A/G	—	uncertain significance
rs766475174	6:108,985,273	A/T	—	uncertain significance
rs1023544612	6:108,985,289	C/T	—	uncertain significance
rs771700859	6:108,985,319	G/A	—	uncertain significance
rs768572858	6:108,985,322	C/G	—	uncertain significance
rs779887975	6:108,985,375	C/G	—	uncertain significance
rs1778981596	6:108,985,515	G/A	—	uncertain significance
rs201417491	6:108,985,530	C/T	—	likely benign
rs2482287824	6:108,985,582	A/G	—	uncertain significance
rs1778991547	6:108,985,705	A/G	—	uncertain significance
rs1448374108	6:108,985,781	C/A	—	uncertain significance
rs2153960	6:108,988,184	G/C	—	—
rs9374040	6:108,997,435	G/A	intron variant	—
rs1935952	6:108,998,905	G/C	regulatory region variant	—
rs1935951	6:108,999,101	G/C	—	—
rs1935949	6:108,999,287	A/G	regulatory region variant	—
rs4946935	6:109,000,742	A/G	—	benign
rs4946936	6:109,003,321	T/C	3 prime UTR variant	benign
rs9400241	6:109,003,989	C/T	—	—

Gene information from NCBI Gene. Variant classifications from ClinVar.