IL6
interleukin 6
Summary
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs142930253 | 7:22,764,868 | C/A | — | uncertain significance |
| rs2069827 | 7:22,765,456 | G/C | coding sequence variant | — |
| rs1800797 | 7:22,766,221 | A/G | coding sequence variant | benign |
| rs1800796 | 7:22,766,246 | G/C | coding sequence variant | — |
| rs7802307 | 7:22,766,433 | T/C | — | — |
| rs7802308 | 7:22,766,434 | T/A | — | — |
| rs1800795 | 7:22,766,645 | G/C | regulatory region variant | risk factor |
| rs13447446 | 7:22,766,708 | G/T | — | — |
| rs142759801 | 7:22,767,134 | C/A | — | benign |
| rs2069830 | 7:22,767,137 | C/T | missense variant | benign |
| rs1360685977 | 7:22,767,162 | C/A | — | uncertain significance |
| rs199925567 | 7:22,767,211 | A/C | — | likely benign |
| rs140764737 | 7:22,767,226 | C/T | — | likely benign |
| rs201410817 | 7:22,767,238 | A/C | — | likely benign |
| rs2069832 | 7:22,767,433 | A/C | — | — |
| rs2069833 | 7:22,767,664 | C/A | — | — |
| rs2069837 | 7:22,768,027 | A/C | — | — |
| rs1474347 | 7:22,768,124 | C/A | regulatory region variant | — |
| rs1524107 | 7:22,768,219 | C/G | — | — |
| rs2066992 | 7:22,768,249 | G/T | regulatory region variant | — |
| rs752964616 | 7:22,768,386 | G/C | — | uncertain significance |
| rs2069840 | 7:22,768,572 | C/G | upstream gene variant | — |
| rs1554606 | 7:22,768,707 | T/A | — | — |
| rs2069845 | 7:22,770,149 | G/C | — | — |
| rs2069860 | 7:22,771,038 | A/T | — | benign |
| rs13306435 | 7:22,771,039 | T/C | synonymous variant | — |
| rs199857749 | 7:22,771,102 | C/A | — | uncertain significance |
| rs2069849 | 7:22,771,156 | C/T | synonymous variant | benign |
| rs2534043271 | 7:22,771,173 | G/C | — | uncertain significance |
| rs13306436 | 7:22,771,296 | G/A | regulatory region variant | — |
| rs2069861 | 7:22,771,654 | C/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.