ITGAM

integrin subunit alpha M

Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Known Variants761 total

rsidPosition (GRCh37)AllelesClassClinVar
rs254434545716:31,271,389G/T—uncertain significance
rs134579646616:31,271,392C/T—uncertain significance
rs75855415016:31,271,393T/G—uncertain significance
rs135843066316:31,271,399T/C—uncertain significance
rs141636379616:31,271,400C/G—likely benign
rs53291103516:31,271,418A/C—uncertain significance
rs96035107216:31,271,420G/A—likely benign
rs207968235016:31,271,426G/C—likely benign
rs148688618216:31,271,430T/A—likely benign
rs3457294316:31,272,353G/Aintron variant—
rs127838084116:31,273,000A/C—likely benign
rs254434975416:31,273,007C/T—likely benign
rs147848698416:31,273,039T/C—likely benign
rs254434988216:31,273,042G/A—uncertain significance
rs214424258816:31,273,043A/G—uncertain significance
rs37388574916:31,273,046C/T—uncertain significance
rs36840694716:31,273,053C/T—likely benign
rs37187376516:31,273,074C/T—likely benign
rs214424276916:31,273,080G/A—likely benign
rs53598652816:31,273,086C/T—likely benign
rs207970207916:31,273,087G/A—uncertain significance
rs77760716216:31,273,095C/T—likely benign
rs14719509316:31,273,096G/A—uncertain significance
rs75937160716:31,273,106T/A—uncertain significance
rs92541944616:31,273,116C/A—likely benign
rs20139099416:31,273,118G/A—uncertain significance
rs214424307116:31,273,122A/T—uncertain significance
rs376432716:31,273,129T/C—benign
rs173220205316:31,273,137G/A—likely benign
rs37758758316:31,273,658A/T——
rs7911399116:31,273,662T/C——
rs75806376916:31,276,699C/T—likely benign
rs214425768616:31,276,700C/T—likely benign
rs128251791416:31,276,715G/A—uncertain significance
rs36890115516:31,276,717G/A—uncertain significance
rs74969020816:31,276,723G/A—uncertain significance
rs148740095516:31,276,727G/C—uncertain significance
rs143630265816:31,276,729G/A—uncertain significance
rs77114073516:31,276,730C/G—uncertain significance
rs131780366216:31,276,731C/T—likely benign
rs125792700216:31,276,734C/G—likely benign
rs55220483716:31,276,742T/C—uncertain significance
rs77559037816:31,276,763G/A—uncertain significance
rs37341325816:31,276,773C/T—likely benign
rs36970412516:31,276,779C/T—likely benign
rs37412724616:31,276,785C/T—likely benign
rs254436192816:31,276,786A/T—uncertain significance
rs74654453016:31,276,798T/G—uncertain significance
rs20000359116:31,276,800C/T—likely benign
rs117875035716:31,276,801G/A—uncertain significance
rs77843527516:31,276,810C/T—uncertain significance
rs114367916:31,276,811G/Amissense variantbenign
rs146653538916:31,276,831C/T—likely benign
rs53578109216:31,276,834C/T—likely benign
rs77221589716:31,276,835G/A—likely benign
rs37127728616:31,276,837C/T—likely benign
rs76075974916:31,276,838G/A—likely benign
rs77668551016:31,276,839G/A—likely benign
rs96054439416:31,277,126C/A—uncertain significance
rs75223240016:31,277,128G/A—likely benign
rs37576639516:31,277,136C/T—likely benign
rs37332297816:31,277,137G/C—uncertain significance
rs126587545916:31,277,145C/T—likely benign
rs147833438716:31,277,146G/A—uncertain significance
rs37702768116:31,277,187C/A—uncertain significance
rs207976073916:31,277,190C/A—likely benign
rs135982472416:31,277,191C/A—uncertain significance
rs77314902216:31,277,192C/T—uncertain significance
rs76620719116:31,277,210G/C—likely benign
rs54847678816:31,277,215C/T—benign
rs76725160716:31,277,216G/T—likely benign
rs214426173516:31,277,332A/G—likely benign
rs135397781516:31,277,344C/T—likely benign
rs78143638116:31,277,347C/A—likely benign
rs121148911616:31,277,360C/T—uncertain significance
rs254436497316:31,277,361C/T—uncertain significance
rs37013364316:31,277,365C/T—likely benign
rs77097232416:31,277,366G/A—uncertain significance
rs207976328916:31,277,379G/A—uncertain significance
rs76730490516:31,277,383T/A—uncertain significance
rs90320458316:31,277,391C/T—uncertain significance
rs77515082516:31,277,392G/A—likely benign
rs135853559716:31,277,405C/T—conflicting classifications of pathogenicity
rs76372916616:31,277,416G/C—likely benign
rs75895110916:31,277,419T/C—likely benign
rs254436535316:31,277,427A/G—uncertain significance
rs75195219216:31,277,431A/G—likely benign
rs36799676916:31,277,432C/T—uncertain significance
rs214426224316:31,277,435C/T—uncertain significance
rs74833157116:31,277,436A/G—uncertain significance
rs77796482416:31,277,465C/T—uncertain significance
rs155546432316:31,277,475T/C—likely benign
rs37086987316:31,277,478C/T—likely benign
rs207983236316:31,282,262T/C—likely benign
rs18211320016:31,282,266C/T—likely benign
rs119582297316:31,282,272C/T—uncertain significance
rs254437915716:31,282,273A/G—uncertain significance
rs99581469116:31,282,276G/T—likely benign
rs207983270816:31,282,279T/A—uncertain significance
rs102766697316:31,282,291T/C—likely benign

Showing 100 of 761 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.