SLC6A4

solute carrier family 6 member 4

Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]

Known Variants150 total

rsidPosition (GRCh37)AllelesClassClinVar
rs15121351717:28,521,583T/C—uncertain significance
rs135170446517:28,521,643A/G—uncertain significance
rs6206866217:28,522,026C/G—likely benign
rs190581353417:28,522,156A/C—uncertain significance
rs20218501917:28,522,247C/T—uncertain significance
rs13805097717:28,522,427T/C—likely benign
rs19052261317:28,522,504T/C—uncertain significance
rs14205861117:28,522,517G/A—benign
rs20170995017:28,522,638G/A—uncertain significance
rs18910620517:28,522,771T/C—likely benign
rs90353078017:28,522,979C/T—uncertain significance
rs19313339517:28,523,062C/G—uncertain significance
rs806660217:28,523,085T/C—benign
rs5603055117:28,523,086G/A—benign
rs806673117:28,523,121T/C—benign
rs20053236517:28,523,282C/G—uncertain significance
rs808102817:28,523,314C/A—benign
rs20184439517:28,523,362G/A—uncertain significance
rs19268340617:28,523,380C/T—uncertain significance
rs74606780417:28,523,389T/G—uncertain significance
rs19987642117:28,523,455G/A—uncertain significance
rs190586746117:28,523,541A/G—uncertain significance
rs55832038817:28,523,574A/G—uncertain significance
rs5614093517:28,523,707C/G—uncertain significance
rs722419917:28,523,726G/T—likely benign
rs19950577917:28,523,747G/A—uncertain significance
rs5613884617:28,523,809A/G—likely benign
rs190587739017:28,523,816A/G—uncertain significance
rs190587798417:28,523,832G/C—uncertain significance
rs19989054117:28,523,898G/A—uncertain significance
rs20050607917:28,524,145C/T—uncertain significance
rs98202430717:28,524,212T/G—uncertain significance
rs5614354817:28,524,263C/T—uncertain significance
rs18565898817:28,524,295C/T—uncertain significance
rs88605277417:28,524,296G/A—uncertain significance
rs88605277517:28,524,347A/G—uncertain significance
rs20015979517:28,524,351C/T—uncertain significance
rs20135555017:28,524,414C/T—uncertain significance
rs88605277617:28,524,445G/A—uncertain significance
rs5582390217:28,524,479G/A—likely benign
rs190590339417:28,524,568C/T—uncertain significance
rs20100205517:28,524,706A/G—uncertain significance
rs381303417:28,524,804A/C3 prime UTR variantlikely benign
rs18556956317:28,524,877G/C—uncertain significance
rs19963496217:28,524,910A/G—uncertain significance
rs5606406217:28,524,936T/C—uncertain significance
rs104217317:28,525,011A/C3 prime UTR variantlikely benign
rs88605277717:28,525,032T/A—uncertain significance
rs18113000617:28,525,033A/G—uncertain significance
rs88605277817:28,525,041C/T—uncertain significance
rs20036323817:28,525,067C/T—uncertain significance
rs20197716717:28,525,115A/G—uncertain significance
rs56726276817:28,525,124C/T—uncertain significance
rs1330679617:28,525,146T/C—likely benign
rs20105363317:28,525,232C/T—uncertain significance
rs102576410217:28,525,288G/A—uncertain significance
rs190592548717:28,525,312G/A—uncertain significance
rs190592680917:28,525,344C/T—uncertain significance
rs88605277917:28,525,377C/G—uncertain significance
rs77673306217:28,525,463C/T—uncertain significance
rs250959637217:28,525,497C/A—uncertain significance
rs76484827317:28,525,535C/G—uncertain significance
rs1244978317:28,527,653A/G——
rs20034386617:28,530,186G/A—likely benign
rs635217:28,530,193T/G—likely benign
rs19960105217:28,530,226A/G—uncertain significance
rs190609014817:28,530,302T/C—uncertain significance
rs379480817:28,531,793C/Tintron variant—
rs205484717:28,532,013G/C——
rs3438819617:28,534,469A/C——
rs20052884117:28,534,828G/A—uncertain significance
rs134018060517:28,536,163T/C—uncertain significance
rs20008008417:28,536,196G/A—uncertain significance
rs76714011417:28,537,586C/T—uncertain significance
rs4127428017:28,537,587G/A—likely benign
rs2891483317:28,537,589A/G—likely benign
rs20122884017:28,537,592G/A—uncertain significance
rs148015182917:28,537,600C/T—uncertain significance
rs20165939317:28,537,614G/A—likely benign
rs125087659717:28,537,616G/A—uncertain significance
rs250960355017:28,537,663A/T—uncertain significance
rs20000610117:28,537,675C/T—uncertain significance
rs635317:28,538,330C/G—uncertain significance
rs75347826017:28,538,348C/G—likely benign
rs2891483217:28,538,374T/Cmissense variantrisk factor
rs75216335517:28,538,382A/G—uncertain significance
rs20063307117:28,538,390C/T—uncertain significance
rs78161970917:28,538,409G/A—uncertain significance
rs20086133417:28,538,451G/A—uncertain significance
rs14070117:28,538,532C/Tintron variant—
rs458330617:28,538,715A/Gintron variant—
rs5590862417:28,539,813G/A—likely benign
rs20114971917:28,539,837C/T—likely benign
rs250960744217:28,542,635C/T—uncertain significance
rs20142553517:28,542,714C/A—uncertain significance
rs7484575217:28,543,148A/G—conflicting classifications of pathogenicity
rs19990920217:28,543,194G/A—uncertain significance
rs13800466217:28,543,225C/A—uncertain significance
rs14070017:28,543,389C/G——
rs190660382217:28,544,180T/A—uncertain significance

Showing 100 of 150 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.