rs10865710

This variant is located in the PPARG gene.

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Research that mentions this SNP (2)

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Clinical relevance of peroxisome proliferator‐activated receptor‐γ gene polymorphisms with sepsis
AssociationN=606Yu Liu et al.(2018)· Journal of Clinical Laboratory Analysis

This case-control association study examined 13 PPAR-γ gene SNPs in 303 sepsis patients and 303 controls from North China Han population. Three SNPs showed significant associations: rs1801282 (Pro12Ala) with decreased sepsis risk (OR=0.55, p=0.024), rs2972164 with increased sepsis risk (OR=1.74, p=0.03), and rs4135275 with increased severe organ dysfunction (OR=2.66, p=0.038). The TAT haplotype (rs2972164-rs4684846-rs17036188) was associated with increased sepsis risk (OR=1.66, p=0.038).

Traits studied:Multiple organ dysfunction syndromeOrgan dysfunctionSepsisSeptic shock
PubMedDOIMetascience Observatory
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Association of peroxisome proliferator-activated receptor gamma polymorphisms with inflammatory bowel disease in a Hungarian cohort
AssociationN=1,164Szilard Poliska et al.(2012)· Inflammatory Bowel Diseases

This case-control association study examined four PPARG polymorphisms in a Hungarian IBD cohort (575 CD, 103 UC patients, 486 controls). The Pro12Ala variant (rs1801282) showed significant protective effect in CD homozygotes (OR=0.33, P=0.03), and haplotype analysis revealed the GAGG haplotype was protective in both CD and UC (OR=0.14 in UC, P=3.78×10⁻⁵), while the GAGC haplotype increased UC risk (OR=6.70, P=3.85×10⁻¹⁰).

Traits studied:Crohn's diseaseInflammatory bowel diseaseUlcerative colitis
PubMedDOIMetascience Observatory

About PPARG

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

View all PPARG variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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