rs11178997
This is a upstream gene variant variant in the TPH2 gene.
▶Research that mentions this SNP (1)
▶Association of Brain-Specific Tryptophan Hydroxylase, TPH2, With Unipolar and Bipolar Disorder in a Northern Swedish, Isolated PopulationAssociationN=719Ann Van Den Bogaert et al.(2006)· Archives of General Psychiatry
This case-control association study examined 719 war-trauma survivors from the Balkans to investigate the role of serotonergic gene polymorphisms in PTSD development. A nominal significant association was found between the HTR1A SNP rs6295 and Brief Symptom Inventory scores in lifetime PTSD patients (P=0.018 dominant model), with the minor C allele conveying increased risk. However, no significant associations were found for TPH2 SNPs rs11178997 and rs1386494, and the HTR1A findings did not survive Bonferroni correction.
About TPH2
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
View all TPH2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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