rs13316193

This variant is located in the OXTR gene.

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Research that mentions this SNP (1)

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Oxytocin system social function impacts in children with attention‐deficit/hyperactivity disorder
AssociationN=198Ayşe Burcu Ayaz et al.(2015)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This case-control study examined three oxytocin receptor (OXTR) gene polymorphisms (rs53576, rs13316193, rs2268493) in 99 Turkish children with ADHD and 99 controls. While no significant differences in genotype distribution were found for rs2268493 (P=0.078), rs53576 (P=0.330), or rs13316193 (P=0.149), the T allele frequency of rs2268493 was significantly higher in controls than ADHD cases (P=0.024). ADHD children showed significantly higher social reciprocity scale (SRS) scores indicating greater social impairment (Z=-21.135, P<0.001). No significant association was found between rs2268493 genotype and SRS scores within the ADHD group.

Traits studied:Attention-Deficit/Hyperactivity Disorder (ADHD)Autism spectrum disorder traitsSocial functioning
PubMedDOIMetascience Observatory

About OXTR

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

View all OXTR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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