rs1761667

badMag 3.5

This is a upstream gene variant variant in the CD36 gene.

Key Literature Trait Associations

Early-onset coronary artery disease

A 2025 meta-analysis of 25 studies (n=11,494) found that A-allele carriers of rs1761667 had higher HDL-C levels yet paradoxically showed increased risk for early-onset coronary artery disease (EOCAD). This counterintuitive finding may reflect CD36's dual roles in lipid transport, scavenger receptor function, and foam cell formation in atherosclerosis. The authors noted the associations were most pronounced in Chinese populations, and anti-atherosclerotic effects were observed for other CD36 variants (rs1049673, rs3211956) rather than rs1761667. Specific odds ratio values were reported in forest plots but not abstracted numerically.

Luo Z et al. “Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of Early-Onset Coronary Artery Disease: A Systematic Review and Meta-Analysis.” Cardiovascular Therapeutics (2025)

Allele A

OR —

p —

N 11,494

Meta-analysis

multi-ancestry

Fat Taste Sensitivity

CD36 (fatty acid translocase) acts as a receptor on taste cells detecting long-chain fatty acids — the molecules responsible for the creamy, rich quality of high-fat foods. The rs1761667 A allele reduces CD36 expression, lowering oral fat detection. A/A individuals have a higher threshold for tasting fat and may consume more fat to reach satisfaction. G/G individuals detect fat more readily and may feel satisfied with less. This variant also associates with cardiometabolic risk factors in some populations.

Melis M et al. “Associations between orosensory perception of oleic acid, the common single nucleotide polymorphisms (rs1761667 and rs1527483) in the CD36 gene, and 6-n-propylthiouracil (PROP) tasting.” Nutrients (2015)

Allele A

OR —

p 3.3e-2

N 64

Candidate gene study

Italian

Keller KL et al. “Genetic influences on oral fat perception and preference: Presented at the symposium "The Taste for Fat: New Discoveries on the Role of Fat in Sensory Perception, Metabolism, Sensory Pleasure and Beyond" held at the Institute of Food Technologists 2011 Annual Meeting, New Orleans, LA, June 12, 2011.” Journal of Food Science 77(3):S143-7 (2012)

Allele A

OR —

p 5.0e-4

Candidate gene study

Piluso F et al. “Associations of CD36 rs1761667 with Fat and Umami Food Perception, Diet Quality, and BMI in Two European Studies.” Foods (basel, Switzerland) (2025)

Allele A

OR —

p 9.6e-1

N 284

Candidate gene study

European

Graham CA et al. “The Associations Between Bitter and Fat Taste Sensitivity, and Dietary Fat Intake: Are They Impacted by Genetic Predisposition?” Chemical Senses (2021)

Allele A

OR —

p 8.0e-3

N 88

Candidate gene study

European

Diószegi J et al. “Genetic Background of Taste Perception, Taste Preferences, and Its Nutritional Implications: A Systematic Review.” Frontiers in Genetics (2019)

Allele A

OR —

p —

Candidate gene study

multi-ancestry

Muthuswamy K et al. “CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake.” Nutrition Bulletin (2023)

Allele A

OR —

p 3.5e-2

Candidate gene study

South Asian

Triglyceride levels

A 2022 systematic review and meta-analysis of 18 studies (n=6,317) found that the A allele at rs1761667 is significantly associated with triglyceride levels in allelic (p<0.001), recessive (p=0.001), and homozygous (p=0.006) genetic models. In Asian subgroup analyses, the A allele was also associated with impaired profiles for total cholesterol, LDL-C, and HDL-C. The underlying mechanism likely involves CD36's role in facilitating fatty acid uptake in peripheral tissues, which influences circulating lipid concentrations. Associations with BMI, waist circumference, and blood pressure were not significant in the overall analysis, and effect sizes were not numerically reported in the abstract.

Yazdanpanah Z et al. “A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults.” Scientific Reports (2022)

Allele A

OR —

p 1.0e-3

N 6,317

Meta-analysis

multi-ancestry

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ClinVar annotation

Benign★☆☆☆

1 submitter6 publications

Type 2 diabetes mellitus

View on ClinVar →

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Research that mentions this SNP (1)

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Genetic variation of FTO: rs1421085 T>C, rs8057044 G>A, rs9939609 T>A, and copy number (CNV) in Mexican Mayan school‐aged children with obesity/overweight and with normal weight

ReviewLizbeth González‐Herrera et al.(2019)· American Journal of Human Biology

A literature review of 70 studies examining single nucleotide polymorphisms (SNPs) associated with obesity in Mexican populations published 2011-2021. The authors identified SNPs with differential behavior in Mexican compared to Caucasian populations, including rs17782313 (MC4R), rs6548238 (TMEM18), rs6265 (BDNF), rs7498665 (SH2B1), and notably rs6232 (PCSK1) associated with early-onset obesity in Mexican youth. The review emphasizes ethnicity-dependent genetic effects on BMI heritability (40-70%) and highlights genes involved in cholesterol metabolism and adipokine signaling pathways.

Traits studied:AdiposityBlood pressureBody mass index (BMI)Cardiovascular risk factorsDyslipidemiaInsulin resistanceMetabolic syndromeObesityOverweightType 2 diabetes

rs1761667

Key Literature Trait Associations

Early-onset coronary artery disease

Fat Taste Sensitivity

Triglyceride levels

ClinVar annotation

Research that mentions this SNP (1)

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