rs2070037
This is a intron variant variant in the HTR2A gene.
▶Research that mentions this SNP (1)
▶Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high‐density schizophrenia familiesAssociationN=1,408Fanous AH et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A family-based association study of 12 SNPs in the HTR2A serotonin receptor gene in 1,408 Irish subjects from 270 high-density schizophrenia families (755 with psychotic illness, 127 with suicidal ideation). Testing for association with psychosis and suicidal ideation using FBAT and PDTPHASE, the authors found two SNPs reaching nominal significance in psychosis (rs659734 p=.05 in FBAT, rs2070037 p=.05 in PDTPHASE) and several haplotypes with modest association (p=.02 to .04), but no significant associations in the suicidal ideation subset and no surviving multiple testing correction. The study does not provide support for HTR2A as a susceptibility gene for psychotic illness or suicidal ideation.
About HTR2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
View all HTR2A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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