rs2228485

This is a synonymous variant in the OXTR gene — it does not change the protein's amino acid sequence.

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Research that mentions this SNP (1)

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Evidence of an Association Between the Vasopressin V1b Receptor Gene (AVPR1B) and Childhood-Onset Mood Disorders
ReviewDempster EL et al.(2007)· Archives of General Psychiatry

This literature review synthesizes findings on oxytocin (OXT) and vasopressin (AVP) receptor gene polymorphisms and their associations with social behaviors and psychiatric traits including autism, depression, schizophrenia, and stress responses. Key polymorphisms include rs53576 and rs2254298 in OXTR, with varying effects on empathy, prosocial behavior, and psychiatric symptomatology depending on genetic background and environmental factors.

Traits studied:AggressionAnxietyAutism spectrum disorderDepressionEmotional withdrawalEmpathyHarm avoidanceNeuroticismOppositional-defiant disorderPost-traumatic stress disorderProsocial behaviorSchizophreniaSocial behaviorStress response
PubMedDOIMetascience Observatory

About OXTR

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

View all OXTR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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