rs2268498

This variant is located in the OXTR gene.

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Research that mentions this SNP (2)

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An interaction between oxytocin and a genetic variation of the oxytocin receptor modulates amygdala activity toward direct gaze: evidence from a pharmacological imaging genetics study
FunctionalN=55Christian Montag et al.(2013)· European Archives of Psychiatry and Clinical Neuroscience

A pharmacological imaging genetics study examining the interaction between intranasal oxytocin administration and OXTR gene variants on amygdala reactivity to direct gaze in 55 healthy males. The rs401015 CT heterozygous carriers showed significantly increased amygdala activation to direct gaze under oxytocin compared to TT homozygotes, while rs2268498 and rs180789 showed no significant interaction effects with oxytocin on gaze processing.

Traits studied:Amygdala activation to direct gazeAutism spectrum disorder (referenced)Gaze processingSocial cognition
PubMedDOIMetascience Observatory
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Evidence of an Association Between the Vasopressin V1b Receptor Gene (AVPR1B) and Childhood-Onset Mood Disorders
ReviewDempster EL et al.(2007)· Archives of General Psychiatry

This literature review synthesizes findings on oxytocin (OXT) and vasopressin (AVP) receptor gene polymorphisms and their associations with social behaviors and psychiatric traits including autism, depression, schizophrenia, and stress responses. Key polymorphisms include rs53576 and rs2254298 in OXTR, with varying effects on empathy, prosocial behavior, and psychiatric symptomatology depending on genetic background and environmental factors.

Traits studied:AggressionAnxietyAutism spectrum disorderDepressionEmotional withdrawalEmpathyHarm avoidanceNeuroticismOppositional-defiant disorderPost-traumatic stress disorderProsocial behaviorSchizophreniaSocial behaviorStress response
PubMedDOIMetascience Observatory

About OXTR

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

View all OXTR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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