rs237902

A comprehensive review of the genetic basis of aggressive behavior, covering candidate genes in neurotransmitter systems (TPH1, TPH2, SLC6A4, DRD4, COMT, MAOA), hypothalamic-pituitary genes (OXT, OXTR, AVPR1A, AVPR1B), and GWAS findings (LRRTM4 rs11126630 p=5.30×10⁻⁸, CDH13 rs11649622 p=4.19×10⁻⁶, FYN rs2148710 p=2.9×10⁻⁸, DYRK1A). The review concludes that genetic predisposition to aggressive behavior involves multiple genes with small individual effects (1-2% each).

A candidate gene association study of 99 healthy Caucasian subjects examining OXTR (oxytocin receptor) variants rs237900 and rs237902 and their effects on personality traits. The study found sexually dimorphic effects on Harm Avoidance, with female carriers of the minor (T) alleles scoring significantly higher (rs237900: p=0.006, rs237902: p=0.01). When sex was controlled for and a sex*genotype interaction term was included in the regression model, the variants explained 11% of the variance in Harm Avoidance (p≤0.01). A novel A217T missense mutation was identified in a highly harm-avoidant male participant.