rs307355

badMag 3.8

This is a upstream gene variant variant in the TAS1R3 gene.

Key Literature Trait Associations

Dental caries

The T allele of rs307355 has been associated with increased dental caries burden across multiple independent cohorts. Chisini et al. (2023), in a large Brazilian birth cohort (n=5,914), found TT homozygotes had 4.52 times higher odds of a high-decay trajectory and 3.35 times higher odds of a high-missing-tooth trajectory over the life course. Haznedaroğlu et al. (2015) identified rs307355 as an independent risk factor for caries in 184 schoolchildren (p=0.04), with the heterozygous genotype linked to moderate caries experience. The mechanism is proposed to involve reduced sweet taste sensitivity in T allele carriers leading to higher sugar consumption to reach satisfactory sweetness perception.

Chisini LA et al. “Sweet Taste Receptor Gene and Caries Trajectory in the Life Course.” Journal of Dental Research (2023)

Allele T

OR 4.52

p —

N 5,914

Preliminary work

Brazilian (European-admixed)

Haznedaroğlu E et al. “Association of sweet taste receptor gene polymorphisms with dental caries experience in school children.” Caries Research (2015)

Allele T

OR —

p 4.0e-2

N 184

Candidate gene study

Turkish

Sweet and Umami Taste Sensitivity

TAS1R3 pairs with TAS1R2 for sweet taste and with TAS1R1 for umami. The rs307355 promoter variant reduces TAS1R3 expression — T allele carriers perceive sucrose as less sweet and may need higher sugar or glutamate concentrations for the same taste satisfaction. This variant explains ~16% of sucrose perception variation in the population. T allele frequency runs from low in Western Europeans to high in East Asians, potentially influencing population-level dietary preferences.

Fushan AA et al. “Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose.” Current Biology : Cb 19(15):1288-1293 (2009)

Allele T

OR —

p 5.0e-6

Preliminary work

Ponnusamy V et al. “T1R2/T1R3 polymorphism affects sweet and fat perception: Correlation between SNP and BMI in the context of obesity development.” Human Genetics (2025)

Allele T

OR —

p 1.0e-4

N 249

Candidate gene study

South Asian

Melis M et al. “Associations between Sweet Taste Sensitivity and Polymorphisms (SNPs) in the TAS1R2 and TAS1R3 Genes, Gender, PROP Taster Status, and Density of Fungiform Papillae in a Genetically Homogeneous Sardinian Cohort.” Nutrients (2022)

Allele T

OR —

p —

N 107

Candidate gene study

European (Sardinian)

Han P et al. “TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.” Nutrients (2018)

Allele T

OR —

p —

N 30

Candidate gene study

multi-ancestry

COVID-19 severity

A pilot study in 196 Italian COVID-19 patients found that homozygous C/C carriers of rs307355 had substantially elevated odds of severe respiratory symptoms compared to T/C heterozygotes: OR 8.11 (95% CI 2.26–51.99) for chest pain and OR 4.83 (95% CI 1.71–17.32) for shortness of breath. The proposed mechanism involves TAS1R3-mediated innate immune signaling in respiratory epithelium, as sweet taste receptors in airway cells have known immunomodulatory functions. These findings are preliminary and require replication in larger, independent cohorts before any clinical conclusions can be drawn.

Santin A et al. “The Bittersweet Symphony of COVID-19: Associations between TAS1Rs and TAS2R38 Genetic Variations and COVID-19 Symptoms.” Life (basel, Switzerland) (2024)

Allele C

OR 8.11

p —

N 196

Candidate gene study

Italian

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…