rs3802177

This is a 3 prime utr variant variant in the SLC30A8 gene.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alanine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.04

p 2.0e-59

N 450,015

Large GWAS

multi-ancestry

Abar L et al. “Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.” Nar Genomics and Bioinformatics 6(2):lqae046 (2024)

Allele A

OR 0.03

p 8.0e-14

N 117,944

Large GWAS

European

type 2 diabetes mellitus

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele G

OR 1.11

p 1.0e-55

N 898,130

Large GWAS

European

Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)

Allele G

OR 0.12

p 2.0e-52

N 659,316

Large GWAS

multi-ancestry

Mahajan A et al. “Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.” Nature Genetics 46(3):234-44 (2014)

Allele G

OR 1.16

p 2.0e-18

N 110,452

Meta-analysisLarge GWAS

multi-ancestry

Morris AP et al. “Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes” Nature Genetics (2012)

Allele G

OR 1.13

p 7.0e-11

N 69,033

Large GWAS

multi-ancestry

Perry JR et al. “Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.” Plos Genetics 8(5):e1002741 (2012)

Allele G

OR 1.23

p 4.0e-8

N 60,651

Large GWAS

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 4.0e-11

N 57,680

Major Consortium StudyLarge GWAS

Hispanic or Latin American

Loh M et al. “Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.” Communications Biology 5(1):329 (2022)

Allele G

OR 0.10

p 2.0e-9

N 50,533

Large GWAS

South Asian

Voight BF et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.” Nature Genetics 42(7):579-89 (2010)

Allele G

OR 1.15

p 1.0e-8

N 47,117

Large GWAS

European

Flannick J et al. “Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.” Nature 570(7759):71-76 (2019)

Allele G

OR 1.16

p 8.0e-14

N 35,912

Large GWAS

multi-ancestry

glucose measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.03

p 6.0e-54

N 450,015

Large GWAS

multi-ancestry

diabetic eye disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 4.0e-27

N 609,979

Major Consortium StudyLarge GWAS

multi-ancestry

Drugs used in diabetes use measurement

Wu Y et al. “Genome-wide association study of medication-use and associated disease in the UK Biobank.” Nature Communications 10(1):1891 (2019)

Allele A

OR 0.10

p 4.0e-14

N 305,913

Major Consortium StudyLarge GWAS

European

leucine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.02

p 1.0e-13

N 450,015

Large GWAS

multi-ancestry

diabetes mellitus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.10

p 2.0e-11

N 57,564

Major Consortium StudyLarge GWAS

Hispanic or Latin American

blood glucose amount

Chung RH et al. “Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.” Diabetologia 64(7):1613-1625 (2021)

Allele A

OR 0.07

p 6.0e-11

N 18,122

Large GWAS

East Asian

body mass index

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele G

OR 0.02

p 5.0e-10

N 158,284

Large GWAS

multi-ancestry

HbA1c measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.06

p 3.0e-15

N 49,152

Major Consortium StudyLarge GWAS

Hispanic or Latin American

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Research that mentions this SNP (1)

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Impact of repeated measures and sample selection on genome‐wide association studies of fasting glucose

AssociationN=9,133Laura J. Rasmussen‐Torvik et al.(2010)· Genetic Epidemiology

This GWAS of fasting glucose in the ARIC study examined 5,782-8,372 individuals across four longitudinal visits and identified five genomic regions significantly associated with fasting glucose (p < 5×10⁻⁸): GCKR, G6PC2, GCK, SLC30A8, and MTNR1B. The study demonstrated that averaging fasting glucose measures across visits improved statistical power and detected additional signals (GCKR rs780094, SLC30A8 rs13266634) not visible in single-visit analyses. Analysis of candidate SNPs revealed significant interactions with diabetes status: associations with fasting glucose were stronger in non-diabetic individuals than in those with prevalent diabetes for multiple SNPs including rs10830963 (MTNR1B), rs560887 (G6PC2), rs4607517 (GCK), and rs780094 (GCKR).

Traits studied:Fasting glucoseType 2 diabetes

PubMed DOI Metascience Observatory

About SLC30A8

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

rs3802177

GWAS Catalog Trait Associations (10)

alanine measurement

type 2 diabetes mellitus

glucose measurement

diabetic eye disease

Drugs used in diabetes use measurement

leucine measurement

diabetes mellitus

blood glucose amount

body mass index

HbA1c measurement

Research that mentions this SNP (1)

About SLC30A8

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