rs6598045
This is a regulatory region variant variant in the IFITM3 gene.
▶Research that mentions this SNP (1)
▶Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 (IFITM3) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virusAssociationN=5,900Yong-Chan Kim et al.(2020)· Immunogenetics
This paper compared ethnic variation in IFITM3 gene polymorphisms (rs12252, rs34481144, rs6598045) associated with pandemic H1N1 influenza susceptibility across multiple populations. The authors found significant differences in risk genotype frequencies among ethnic groups: the rs12252 CC genotype was most prevalent in East Asian populations (30%) but absent in Europeans, while rs34481144 AA was highest in Europeans (22%) but absent in East Asian/Korean populations, and rs6598045 showed variation with highest frequencies in Europeans (79%).
About IFITM3
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
View all IFITM3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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