rs7069102
This is a intron variant variant in the SIRT1 gene.
▶Research that mentions this SNP (1)
▶No significant association between SIRT1 gene and methamphetamine‐induced psychosis in the Japanese populationAssociationN=941Taro Kishi et al.(2011)· Human Psychopharmacology: Clinical and Experimental
This case-control study in Chinese Han population identified that the G allele of SIRT1 tagSNP rs7069102 is associated with increased myocardial infarction (MI) risk (OR = 1.57, 95% CI = 1.15–2.16). The haplotype rs7069102G-rs3818292A-rs4746720T also conferred increased MI susceptibility, with stronger effects observed in younger subjects (≤55 years old).
About SIRT1
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
View all SIRT1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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