rs78162420
This is a variant in the TPH2 gene that changes a serine to an tyrosine.
▶ClinVar annotation
Attention deficit-hyperactivity disorder, susceptibility to, 7 (ADHD7); Major depressive disorder (MDD); Tryptophan 5-monooxygenase deficiency
View on ClinVar →About TPH2
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016]
View all TPH2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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