Polygenic Risk Scores — EXPERIMENTAL — currently has known issues!!
Ancestry Context
Selected Ancestry (used for PRS)
EUR — European
Estimated Ancestry (computed)
98% European
PRS scores are calibrated against reference distributions from the selected ancestry group.
2.9× higher risk than average
Of people with your genetics,
67.5%
do not have trait
32.5%
have trait
In the general population,
88.7%
do not have trait
11.3%
have trait
Population prevalence: CDC National Diabetes Statistics Report 2022: 11.3% of US adults. Source
1.1× higher risk than average
Of people with your genetics,
87.8%
do not have trait
12.2%
have trait
In the general population,
89.3%
do not have trait
10.7%
have trait
Population prevalence: Alzheimer's Association 2024: 10.7% of Americans aged 65+ have Alzheimer's. Source
1.0× higher risk than average
Of people with your genetics,
88.9%
do not have trait
11.1%
have trait
In the general population,
89.3%
do not have trait
10.7%
have trait
Population prevalence: Alzheimer's Association 2024: 10.7% of Americans aged 65+ have Alzheimer's. Source
1.1× higher risk than average
Of people with your genetics,
88.3%
do not have trait
11.7%
have trait
In the general population,
89.3%
do not have trait
10.7%
have trait
Population prevalence: Alzheimer's Association 2024: 10.7% of Americans aged 65+ have Alzheimer's. Source
1.1× higher risk than average
Of people with your genetics,
85.8%
do not have trait
14.2%
have trait
In the general population,
86.8%
do not have trait
13.2%
have trait
Population prevalence: NCI SEER: 13.2% lifetime risk of female breast cancer (2018-2020 data). Source
1.0× lower risk than average
Of people with your genetics,
87.4%
do not have trait
12.6%
have trait
In the general population,
86.8%
do not have trait
13.2%
have trait
Population prevalence: NCI SEER: 13.2% lifetime risk of female breast cancer (2018-2020 data). Source
1.9× lower risk than average
Of people with your genetics,
94.3%
do not have trait
5.7%
have trait
In the general population,
89.3%
do not have trait
10.7%
have trait
Population prevalence: Alzheimer's Association 2024: 10.7% of Americans aged 65+ have Alzheimer's/dementia. Source
13.5× lower risk than average
Of people with your genetics,
99.1%
do not have trait
0.9%
have trait
In the general population,
87.2%
do not have trait
12.8%
have trait
Population prevalence: NCI SEER: 12.8% lifetime risk of prostate cancer (2018-2020 data). Source
1.5× lower risk than average
Of people with your genetics,
91.4%
do not have trait
8.6%
have trait
In the general population,
86.8%
do not have trait
13.2%
have trait
Population prevalence: NCI SEER: 13.2% lifetime risk of female breast cancer (2018-2020 data). Source
16.7× lower risk than average
Of people with your genetics,
99.6%
do not have trait
0.4%
have trait
In the general population,
93.5%
do not have trait
6.5%
have trait
Population prevalence: CDC NHANES 2017-2020: 6.5% of US adults aged 20+ have CHD. Source
5.5× lower risk than average
Of people with your genetics,
99.5%
do not have trait
0.5%
have trait
In the general population,
97.0%
do not have trait
3.0%
have trait
Population prevalence: AHA 2023: ~3.0% of US adults have had a stroke. Source
| ID | Trait | Variants | Raw Score | Percentile |
|---|---|---|---|---|
| PGS000031 | Type 2 diabetes (T2D) | 62 | 6.372 | 92 |
| PGS002280 | Alzheimer's disease | 83 | 5.516 | 87 |
| PGS004590 | Alzheimer's disease | 362 | -2.892 | 75 |
| PGS004008 | Alzheimer's disease | 5,662 | -0.1597 | 68 |
| PGS003992 | Alzheimer's disease | 1,136,108 | 0.04630 | 67 |
| PGS000002 | ER-positive breast cancer | 77 | 0.6435 | 64 |
| PGS004228 | Alzheimer's disease | 8,861 | -20.01 | 62 |
| PGS000001 | Breast cancer | 77 | 0.5079 | 52 |
| PGS003514 | Standing height | 979,739 | 3.847 | 45 |
| PGS005170 | All-cause dementia | 1,320,050 | 2.400 | 33 |
| PGS002753 | Alzheimer's disease | 1,091,909 | -0.3208 | 31 |
| PGS002249 | Alzheimer's disease | 249,248 | 119.4 | 27 |
| PGS002035 | Dementia | 39,751 | -0.0003671 | 8 |
| PGS000662 | Prostate cancer | 269 | 21.76 | 8 |
| PGS000003 | ER-negative breast cancer | 77 | -0.1201 | 7 |
| PGS000018 | Coronary artery disease | 1,745,017 | -1.451 | 2 |
| PGS000039 | Ischemic stroke | 3,225,164 | 1.626 | <1 |
What is a polygenic risk score?
A polygenic risk score (PRS) combines the effects of many genetic variants to estimate your relative risk for a trait or disease. Each variant contributes a small amount — the PRS aggregates thousands of these effects into a single number.
Gene Wizard uses scores from the PGS Catalog, the largest open database of published polygenic scores, and normalizes your result against reference populations so you can see where you fall.