Polygenic Risk Scores — EXPERIMENTAL — currently has known issues!!
Ancestry Context
Selected Ancestry (used for PRS)
EUR — European
Estimated Ancestry (computed)
98% European
PRS scores are calibrated against reference distributions from the selected ancestry group.
Type 2 diabetes (T2D)
2.9× higher risk than average(32.5% lifetime risk vs 11.3% background risk)
Alzheimer's disease
87th percentile
Alzheimer's disease
1.1× higher risk than average(12.2% lifetime risk vs 10.7% background risk)
Alzheimer's disease
1.0× higher risk than average(11.1% lifetime risk vs 10.7% background risk)
Alzheimer's disease
1.1× higher risk than average(11.7% lifetime risk vs 10.7% background risk)
ER-positive breast cancer
1.1× higher risk than average(14.2% lifetime risk vs 13.2% background risk)
Alzheimer's disease
62nd percentile
Breast cancer
1.0× lower risk than average(12.6% lifetime risk vs 13.2% background risk)
Standing height
45th percentile
All-cause dementia
1.9× lower risk than average(5.7% lifetime risk vs 10.7% background risk)
Alzheimer's disease
31st percentile
Alzheimer's disease
27th percentile
Dementia
8th percentile
Prostate cancer
13.5× lower risk than average(0.9% lifetime risk vs 12.8% background risk)
ER-negative breast cancer
1.5× lower risk than average(8.6% lifetime risk vs 13.2% background risk)
Coronary artery disease
16.7× lower risk than average(0.4% lifetime risk vs 6.5% background risk)
Ischemic stroke
5.5× lower risk than average(0.5% lifetime risk vs 3.0% background risk)
| ID | Trait | Variants | Raw Score | Percentile |
|---|---|---|---|---|
| PGS000031 | Type 2 diabetes (T2D) | 62 | 6.372 | 92 |
| PGS002280 | Alzheimer's disease | 83 | 5.516 | 87 |
| PGS004590 | Alzheimer's disease | 362 | -2.892 | 75 |
| PGS004008 | Alzheimer's disease | 5,662 | -0.1597 | 68 |
| PGS003992 | Alzheimer's disease | 1,136,108 | 0.04630 | 67 |
| PGS000002 | ER-positive breast cancer | 77 | 0.6435 | 64 |
| PGS004228 | Alzheimer's disease | 8,861 | -20.01 | 62 |
| PGS000001 | Breast cancer | 77 | 0.5079 | 52 |
| PGS003514 | Standing height | 979,739 | 3.847 | 45 |
| PGS005170 | All-cause dementia | 1,320,050 | 2.400 | 33 |
| PGS002753 | Alzheimer's disease | 1,091,909 | -0.3208 | 31 |
| PGS002249 | Alzheimer's disease | 249,248 | 119.4 | 27 |
| PGS002035 | Dementia | 39,751 | -0.0003671 | 8 |
| PGS000662 | Prostate cancer | 269 | 21.76 | 8 |
| PGS000003 | ER-negative breast cancer | 77 | -0.1201 | 7 |
| PGS000018 | Coronary artery disease | 1,745,017 | -1.451 | 2 |
| PGS000039 | Ischemic stroke | 3,225,164 | 1.626 | <1 |
What is a polygenic risk score?
A polygenic risk score (PRS) combines the effects of many genetic variants to estimate your relative risk for a trait or disease. Each variant contributes a small amount — the PRS aggregates thousands of these effects into a single number.
Gene Wizard uses scores from the PGS Catalog, the largest open database of published polygenic scores, and normalizes your result against reference populations so you can see where you fall.
How we choose which scores to include
We screen every score in the PGS Catalog and keep only those with the strongest published evidence. Each candidate is ranked by its predictive accuracy (AUC) in independent validation cohorts, the number of separate studies that have replicated it, and how broadly it has been validated across ancestries. A score must clear a minimum accuracy threshold and have been validated in at least two independent cohorts to qualify. Where several scores cover the same condition, we keep only the single best-validated one — so each trait shown here reflects the most reliable score currently available, not simply the newest or largest.