AANAT
aralkylamine N-acetyltransferase
Summary
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3760138 | 17:74,463,109 | G/T | downstream gene variant | — |
| rs4238989 | 17:74,463,388 | C/G | downstream gene variant | — |
| rs61739395 | 17:74,464,836 | C/T | — | benign |
| rs141006262 | 17:74,464,914 | G/A | — | likely benign |
| rs139765369 | 17:74,464,920 | C/T | — | uncertain significance |
| rs754521929 | 17:74,464,982 | G/C | — | uncertain significance |
| rs2509749090 | 17:74,465,258 | T/C | — | uncertain significance |
| rs777893542 | 17:74,465,303 | G/A | — | uncertain significance |
| rs146430405 | 17:74,465,321 | G/A | — | uncertain significance |
| rs867255223 | 17:74,465,389 | G/C | — | uncertain significance |
| rs749382858 | 17:74,465,393 | A/G | — | uncertain significance |
| rs1170739515 | 17:74,465,405 | T/A | — | uncertain significance |
| rs140194920 | 17:74,465,794 | T/C | — | likely benign |
| rs150357567 | 17:74,465,811 | G/A | — | uncertain significance |
| rs200468284 | 17:74,465,812 | C/T | — | likely benign |
| rs28936679 | 17:74,465,813 | G/A | missense variant | uncertain significance |
| rs970708682 | 17:74,465,819 | C/T | — | uncertain significance |
| rs747872748 | 17:74,465,820 | G/A | — | uncertain significance |
| rs553892291 | 17:74,465,853 | G/A | — | uncertain significance |
| rs1286672780 | 17:74,465,894 | G/C | — | uncertain significance |
| rs2071031 | 17:74,465,896 | C/T | — | benign |
| rs143874240 | 17:74,465,909 | G/A | — | uncertain significance |
| rs773528016 | 17:74,465,912 | G/A | — | uncertain significance |
| rs780002243 | 17:74,465,942 | A/T | — | uncertain significance |
| rs58504104 | 17:74,465,971 | C/A | — | benign |
| rs150881412 | 17:74,465,984 | C/T | — | uncertain significance |
| rs754158557 | 17:74,465,987 | A/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.