AATF
apoptosis antagonizing transcription factor
Summary
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2306658 | 17:35,306,312 | G/C | regulatory region variant | — |
| rs752205542 | 17:35,306,430 | C/G | — | uncertain significance |
| rs369810199 | 17:35,306,445 | T/C | — | uncertain significance |
| rs760414667 | 17:35,306,469 | T/G | — | uncertain significance |
| rs753366095 | 17:35,306,486 | G/C | — | uncertain significance |
| rs764863894 | 17:35,306,496 | C/T | — | uncertain significance |
| rs1463175028 | 17:35,307,572 | C/G | — | uncertain significance |
| rs775138504 | 17:35,307,622 | C/T | — | uncertain significance |
| rs1398084831 | 17:35,307,686 | G/C | — | uncertain significance |
| rs140132823 | 17:35,310,234 | G/A | — | uncertain significance |
| rs1158096616 | 17:35,310,258 | A/T | — | uncertain significance |
| rs145557208 | 17:35,310,263 | G/A | — | uncertain significance |
| rs145311864 | 17:35,310,392 | A/G | — | uncertain significance |
| rs1018671030 | 17:35,310,426 | A/G | — | uncertain significance |
| rs201302577 | 17:35,310,428 | G/A | — | uncertain significance |
| rs202139717 | 17:35,310,435 | G/A | — | uncertain significance |
| rs1352985479 | 17:35,310,453 | A/G | — | uncertain significance |
| rs2508600436 | 17:35,310,519 | A/G | — | uncertain significance |
| rs765216865 | 17:35,310,544 | T/A | — | uncertain significance |
| rs1054553638 | 17:35,311,108 | C/G | — | uncertain significance |
| rs796424851 | 17:35,311,115 | C/T | — | uncertain significance |
| rs772058410 | 17:35,311,181 | C/T | — | uncertain significance |
| rs141862092 | 17:35,344,003 | T/G | — | uncertain significance |
| rs200375945 | 17:35,344,024 | C/T | — | uncertain significance |
| rs779784024 | 17:35,345,855 | G/A | — | uncertain significance |
| rs369773296 | 17:35,345,871 | G/A | — | uncertain significance |
| rs2508653827 | 17:35,345,874 | G/C | — | uncertain significance |
| rs2508653853 | 17:35,345,879 | G/A | — | uncertain significance |
| rs138690067 | 17:35,345,909 | G/A | — | uncertain significance |
| rs759748313 | 17:35,345,913 | A/G | — | uncertain significance |
| rs560525426 | 17:35,345,933 | C/T | — | uncertain significance |
| rs1324896577 | 17:35,345,958 | G/C | — | uncertain significance |
| rs1197518880 | 17:35,345,987 | A/G | — | uncertain significance |
| rs141988516 | 17:35,345,996 | C/G | — | uncertain significance |
| rs746395950 | 17:35,346,631 | C/G | — | uncertain significance |
| rs924491861 | 17:35,346,636 | C/T | — | uncertain significance |
| rs139574552 | 17:35,346,649 | G/A | — | uncertain significance |
| rs763695386 | 17:35,346,702 | G/A | — | uncertain significance |
| rs2508655919 | 17:35,346,707 | A/C | — | uncertain significance |
| rs1222561215 | 17:35,348,104 | A/G | — | uncertain significance |
| rs113370294 | 17:35,359,782 | G/A | downstream gene variant | — |
| rs1045687198 | 17:35,376,326 | G/A | — | uncertain significance |
| rs2544311060 | 17:35,378,265 | A/T | — | uncertain significance |
| rs186218230 | 17:35,384,425 | G/A | intron variant | — |
| rs748675019 | 17:35,388,943 | T/C | — | uncertain significance |
| rs1280677935 | 17:35,413,906 | A/G | — | uncertain significance |
| rs367770515 | 17:35,413,947 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.