AATF

apoptosis antagonizing transcription factor

Summary

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

Known Variants47 total

rsidPosition (GRCh37)AllelesClassClinVar
rs230665817:35,306,312G/Cregulatory region variant
rs75220554217:35,306,430C/Guncertain significance
rs36981019917:35,306,445T/Cuncertain significance
rs76041466717:35,306,469T/Guncertain significance
rs75336609517:35,306,486G/Cuncertain significance
rs76486389417:35,306,496C/Tuncertain significance
rs146317502817:35,307,572C/Guncertain significance
rs77513850417:35,307,622C/Tuncertain significance
rs139808483117:35,307,686G/Cuncertain significance
rs14013282317:35,310,234G/Auncertain significance
rs115809661617:35,310,258A/Tuncertain significance
rs14555720817:35,310,263G/Auncertain significance
rs14531186417:35,310,392A/Guncertain significance
rs101867103017:35,310,426A/Guncertain significance
rs20130257717:35,310,428G/Auncertain significance
rs20213971717:35,310,435G/Auncertain significance
rs135298547917:35,310,453A/Guncertain significance
rs250860043617:35,310,519A/Guncertain significance
rs76521686517:35,310,544T/Auncertain significance
rs105455363817:35,311,108C/Guncertain significance
rs79642485117:35,311,115C/Tuncertain significance
rs77205841017:35,311,181C/Tuncertain significance
rs14186209217:35,344,003T/Guncertain significance
rs20037594517:35,344,024C/Tuncertain significance
rs77978402417:35,345,855G/Auncertain significance
rs36977329617:35,345,871G/Auncertain significance
rs250865382717:35,345,874G/Cuncertain significance
rs250865385317:35,345,879G/Auncertain significance
rs13869006717:35,345,909G/Auncertain significance
rs75974831317:35,345,913A/Guncertain significance
rs56052542617:35,345,933C/Tuncertain significance
rs132489657717:35,345,958G/Cuncertain significance
rs119751888017:35,345,987A/Guncertain significance
rs14198851617:35,345,996C/Guncertain significance
rs74639595017:35,346,631C/Guncertain significance
rs92449186117:35,346,636C/Tuncertain significance
rs13957455217:35,346,649G/Auncertain significance
rs76369538617:35,346,702G/Auncertain significance
rs250865591917:35,346,707A/Cuncertain significance
rs122256121517:35,348,104A/Guncertain significance
rs11337029417:35,359,782G/Adownstream gene variant
rs104568719817:35,376,326G/Auncertain significance
rs254431106017:35,378,265A/Tuncertain significance
rs18621823017:35,384,425G/Aintron variant
rs74867501917:35,388,943T/Cuncertain significance
rs128067793517:35,413,906A/Guncertain significance
rs36777051517:35,413,947G/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.