ABCB8

ATP binding cassette subfamily B member 8

Summary

This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Known Variants55 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7502323347:150,725,622G/Tuncertain significance
rs12215598867:150,725,663C/Tuncertain significance
rs17960368457:150,725,680G/Tuncertain significance
rs69759817:150,730,712G/Abenign
rs5668643367:150,730,732G/Auncertain significance
rs7735936477:150,730,772G/Auncertain significance
rs17962277397:150,730,835G/Tuncertain significance
rs1453931097:150,730,899C/Tbenign
rs1498975347:150,730,926C/Tbenign
rs1177931047:150,730,966C/Gbenign
rs13964116877:150,731,369G/Auncertain significance
rs1508721857:150,731,381G/Auncertain significance
rs7567166227:150,731,417G/Tuncertain significance
rs77767727:150,731,519C/Tbenign
rs1142125817:150,731,630C/Tbenign
rs12492152927:150,731,632T/Cuncertain significance
rs1902747567:150,732,729G/Auncertain significance
rs12210938737:150,732,731C/Guncertain significance
rs7793584587:150,732,741T/Cuncertain significance
rs7740094497:150,732,789G/Tuncertain significance
rs7588302227:150,732,813G/Tuncertain significance
rs24863445097:150,732,975A/Guncertain significance
rs3713239317:150,733,160G/Tuncertain significance
rs7559026897:150,733,212C/Tuncertain significance
rs7727905617:150,733,633A/Guncertain significance
rs5407821817:150,737,603G/Tuncertain significance
rs2009043087:150,737,673C/Guncertain significance
rs616520807:150,737,688G/Tbenign
rs5720705687:150,737,696G/Alikely benign
rs5619553807:150,737,925C/Tuncertain significance
rs7572276677:150,737,937G/Auncertain significance
rs1497423697:150,737,991G/Auncertain significance
rs17964496277:150,738,189A/Guncertain significance
rs7477843757:150,738,224G/Auncertain significance
rs7645789627:150,739,121T/Guncertain significance
rs1481915407:150,739,135C/Guncertain significance
rs3744426807:150,739,136G/Alikely benign
rs7800042467:150,739,142C/Tuncertain significance
rs1502977257:150,739,153G/Auncertain significance
rs5653541057:150,739,174G/Auncertain significance
rs7746771607:150,741,097G/Auncertain significance
rs7736297777:150,741,108G/Auncertain significance
rs24863798187:150,741,114G/Tuncertain significance
rs7482253637:150,741,184G/Auncertain significance
rs784657617:150,741,191A/Gbenign
rs1447536947:150,741,193A/Guncertain significance
rs17965527527:150,741,282G/Auncertain significance
rs3752805137:150,741,297C/Tlikely benign
rs1441656577:150,742,328C/Tlikely benign
rs7802999357:150,742,329G/Auncertain significance
rs21172470267:150,742,330G/Auncertain significance
rs1410531277:150,742,384C/Tuncertain significance
rs7478356007:150,742,390C/Tuncertain significance
rs17965857447:150,742,399A/Cuncertain significance
rs7764626737:150,742,417G/Alikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.