ABCC3

ATP binding cassette subfamily C member 3

Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Known Variants99 total

rsidPosition (GRCh37)AllelesClassClinVar
rs479366517:48,712,087C/Tregulatory region variant
rs20188664617:48,712,336G/Clikely benign
rs414840517:48,713,568T/Gregulatory region variant
rs6205974617:48,733,187C/Tlikely benign
rs254596009917:48,733,238T/Guncertain significance
rs14559614017:48,733,288C/Tlikely benign
rs147199592217:48,733,295C/Tuncertain significance
rs55330486217:48,733,317G/Auncertain significance
rs76057675417:48,733,329G/Auncertain significance
rs3492603417:48,733,349T/Cbenign
rs118732210117:48,733,353T/Cuncertain significance
rs414841217:48,733,815T/Cintron variant
rs20130916317:48,734,135C/Guncertain significance
rs3577796817:48,734,136G/Abenign
rs86862061117:48,734,139C/Auncertain significance
rs147539460717:48,734,180G/Tuncertain significance
rs156782879417:48,734,486T/Cuncertain significance
rs53827058117:48,734,493G/Abenign
rs20067064817:48,735,465G/Auncertain significance
rs20144304317:48,735,494C/Guncertain significance
rs73992317:48,735,774G/Aintron variant
rs75201681817:48,735,833G/Auncertain significance
rs214660933417:48,736,714A/Glikely benign
rs75373611017:48,738,321G/Alikely benign
rs77206490517:48,738,331A/Guncertain significance
rs102301115917:48,738,367C/Tuncertain significance
rs140654784117:48,741,198C/Guncertain significance
rs76853069617:48,741,366A/Guncertain significance
rs254596878417:48,741,377G/Tuncertain significance
rs14292492117:48,741,390G/Alikely benign
rs36835484717:48,741,417A/Guncertain significance
rs254596984317:48,742,520G/Cuncertain significance
rs196749390817:48,742,536C/Tuncertain significance
rs77901525617:48,742,574G/Auncertain significance
rs20064816017:48,742,585C/Tlikely benign
rs77518078917:48,744,940C/Tuncertain significance
rs77995476217:48,744,975A/Guncertain significance
rs13942580217:48,744,995C/Tlikely benign
rs75942932617:48,745,251G/Auncertain significance
rs20000848117:48,745,257G/Auncertain significance
rs76844283917:48,745,797G/Auncertain significance
rs1156860817:48,745,828G/Amissense variant
rs254597259017:48,745,874C/Tlikely benign
rs254597296217:48,746,241C/Tuncertain significance
rs76575680017:48,746,541G/Auncertain significance
rs254597346517:48,746,714G/Auncertain significance
rs132012536617:48,746,726A/Guncertain significance
rs76772216417:48,746,803C/Guncertain significance
rs105541841117:48,746,819T/Cuncertain significance
rs13842919717:48,746,823G/Tuncertain significance
rs37338635417:48,750,403T/Guncertain significance
rs14991002817:48,750,472C/Tlikely benign
rs76600227117:48,750,852G/Auncertain significance
rs55404596817:48,750,877C/Auncertain significance
rs196769575517:48,750,884A/Tuncertain significance
rs76762152817:48,750,887G/Auncertain significance
rs75390349817:48,750,905G/Cuncertain significance
rs115997199317:48,750,929G/Auncertain significance
rs75879966317:48,751,015G/Tuncertain significance
rs37330785117:48,752,732G/Tuncertain significance
rs94240795917:48,752,760T/Guncertain significance
rs77425717817:48,753,024G/Auncertain significance
rs75311440817:48,753,032C/Tuncertain significance
rs3450205817:48,753,045G/Abenign
rs13837640117:48,753,065G/Auncertain significance
rs98652423217:48,753,111A/Tuncertain significance
rs414841617:48,753,423C/Tsynonymous variant
rs37283397417:48,753,442A/Guncertain significance
rs55892459717:48,753,675C/Tlikely benign
rs133063401617:48,753,681G/Auncertain significance
rs76631163717:48,753,770C/Tuncertain significance
rs76427139217:48,753,801A/Guncertain significance
rs75937296717:48,753,884A/Glikely benign
rs76070742817:48,753,892C/Guncertain significance
rs1294381217:48,754,240T/G
rs76325025317:48,755,165A/Guncertain significance
rs254598201617:48,755,204G/Auncertain significance
rs74932791417:48,755,237G/Cuncertain significance
rs76802270417:48,755,279T/Cuncertain significance
rs1156858317:48,755,450A/Gbenign
rs196786355117:48,755,482G/Auncertain significance
rs1156858217:48,755,517C/Tlikely benign
rs130096753017:48,755,552T/Cuncertain significance
rs77754537917:48,760,987A/Guncertain significance
rs77079411017:48,760,993G/Auncertain significance
rs77397280917:48,760,995C/Tuncertain significance
rs37147624017:48,761,017C/Guncertain significance
rs18357637817:48,761,058C/Tuncertain significance
rs1156858917:48,761,363G/Alikely benign
rs15060169217:48,761,385A/Glikely benign
rs11487700017:48,761,409C/Tlikely benign
rs14371054917:48,762,190C/Tuncertain significance
rs55914991017:48,764,916G/Auncertain significance
rs20124215517:48,764,940C/Tuncertain significance
rs52776261517:48,764,941G/Auncertain significance
rs254598914517:48,764,991G/Cuncertain significance
rs75703155117:48,765,021C/Auncertain significance
rs56855914817:48,766,255C/A
rs78128951817:48,768,532G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.