ABI2
abl interactor 2
Summary
Enables several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Part of SCAR complex. Is active in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1559127171 | 2:204,193,275 | C/T | — | uncertain significance |
| rs116426890 | 2:204,196,618 | C/T | upstream gene variant | — |
| rs761796222 | 2:204,231,733 | G/A | — | uncertain significance |
| rs752975781 | 2:204,231,750 | A/G | — | uncertain significance |
| rs61601697 | 2:204,236,984 | A/G | — | — |
| rs777608395 | 2:204,244,989 | A/G | — | uncertain significance |
| rs2479364465 | 2:204,245,027 | G/T | — | uncertain significance |
| rs141392713 | 2:204,245,066 | A/G | — | uncertain significance |
| rs11675251 | 2:204,249,399 | A/T | — | — |
| rs778466632 | 2:204,260,416 | C/T | — | uncertain significance |
| rs770750525 | 2:204,260,464 | A/G | — | uncertain significance |
| rs766821803 | 2:204,267,420 | T/A | — | uncertain significance |
| rs2484004977 | 2:204,267,430 | G/A | — | uncertain significance |
| rs1376877 | 2:204,272,090 | C/T | intron variant | — |
| rs149356092 | 2:204,276,070 | T/A | — | uncertain significance |
| rs2488447559 | 2:204,291,965 | A/C | — | uncertain significance |
| rs374111967 | 2:204,292,046 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.