ACOT1

acyl-CoA thioesterase 1

Summary

Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants33 total

rsidPosition (GRCh37)AllelesClassClinVar
rs77899340114:74,004,171G/A—uncertain significance
rs77202372314:74,004,177C/A—uncertain significance
rs19957359414:74,004,210G/A—benign
rs75375686514:74,004,275G/A—benign
rs77904435014:74,004,293C/T—likely benign
rs74705223914:74,004,324G/C—uncertain significance
rs76619682714:74,004,392C/T—likely benign
rs78143891714:74,004,447G/A—uncertain significance
rs135036048614:74,004,475G/A—uncertain significance
rs250430286614:74,004,486T/G—likely benign
rs77053472414:74,004,507T/G—likely benign
rs20038163414:74,004,508A/G—conflicting classifications of pathogenicity
rs75629824614:74,004,568T/G—uncertain significance
rs76270452614:74,008,259C/T—uncertain significance
rs76846270414:74,008,260G/A—uncertain significance
rs250431253214:74,008,274G/C—uncertain significance
rs77841892114:74,008,344C/T—uncertain significance
rs77963482114:74,009,767G/A—uncertain significance
rs250431639014:74,009,772G/A—uncertain significance
rs57053493914:74,009,797G/A—uncertain significance
rs77677869414:74,009,815T/C—uncertain significance
rs188915010514:74,009,847G/A—uncertain significance
rs77641671614:74,009,875T/C—uncertain significance
rs14716829414:74,009,889C/T—uncertain significance
rs14859888114:74,009,917T/C—benign
rs14116160914:74,009,920G/C—benign
rs74688222214:74,009,922G/A—uncertain significance
rs54303283314:74,009,942G/C—uncertain significance
rs37084108114:74,010,076A/G—uncertain significance
rs119319262114:74,010,108T/C—uncertain significance
rs53032428814:74,010,146G/C—uncertain significance
rs188917304014:74,010,199T/C—uncertain significance
rs6198713114:74,010,331A/G—likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.