ACR
acrosin
Summary
Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs145373249 | 22:51,176,664 | A/G | — | benign |
| rs368378183 | 22:51,176,729 | C/T | — | likely benign |
| rs79314756 | 22:51,176,734 | C/T | — | benign |
| rs191165317 | 22:51,177,751 | G/A | — | uncertain significance |
| rs376377088 | 22:51,177,763 | G/T | — | uncertain significance |
| rs2518448686 | 22:51,177,788 | G/A | — | pathogenic |
| rs1064733 | 22:51,177,812 | C/T | — | uncertain significance |
| rs149456732 | 22:51,178,150 | G/A | — | uncertain significance |
| rs6010072 | 22:51,181,519 | A/G | upstream gene variant | — |
| rs6009961 | 22:51,182,485 | A/G | — | benign |
| rs371232787 | 22:51,182,522 | G/C | — | uncertain significance |
| rs746236075 | 22:51,182,599 | G/A | — | uncertain significance |
| rs753029481 | 22:51,183,171 | C/T | — | uncertain significance |
| rs754872586 | 22:51,183,186 | G/A | — | uncertain significance |
| rs543333675 | 22:51,183,252 | C/T | — | uncertain significance |
| rs140584689 | 22:51,183,253 | G/A | — | likely benign |
| rs5771002 | 22:51,183,255 | A/G | — | benign |
| rs1320079223 | 22:51,183,283 | C/T | — | uncertain significance |
| rs770629027 | 22:51,183,295 | C/T | — | uncertain significance |
| rs776024191 | 22:51,183,301 | C/T | — | uncertain significance |
| rs1485964688 | 22:51,183,357 | C/T | — | uncertain significance |
| rs1046181499 | 22:51,183,364 | C/G | — | uncertain significance |
| rs1464574890 | 22:51,183,367 | G/A | — | uncertain significance |
| rs773438105 | 22:51,183,382 | G/A | — | uncertain significance |
| rs1201421287 | 22:51,183,384 | C/A | — | uncertain significance |
| rs762995513 | 22:51,183,412 | C/T | — | uncertain significance |
| rs1308967153 | 22:51,183,558 | G/C | — | uncertain significance |
| rs773349529 | 22:51,183,586 | A/G | — | uncertain significance |
| rs1476008333 | 22:51,183,628 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.