ADAM28

ADAM metallopeptidase domain 28

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Known Variants51 total

rsidPosition (GRCh37)AllelesClassClinVar
rs3752655788:24,157,490G/Alikely benign
rs1441936838:24,168,880T/Auncertain significance
rs9368438978:24,168,947T/Cuncertain significance
rs8866259988:24,170,906A/Guncertain significance
rs24867602548:24,170,932T/Cuncertain significance
rs1402300448:24,170,956C/Abenign
rs7556463298:24,171,026G/Auncertain significance
rs1470920308:24,171,056T/Guncertain significance
rs3679074638:24,171,066C/Guncertain significance
rs2008391678:24,177,788A/Guncertain significance
rs1483242058:24,181,375C/Tuncertain significance
rs12857523408:24,181,386A/Guncertain significance
rs24869399988:24,181,387T/Cuncertain significance
rs3694428258:24,181,504C/Tuncertain significance
rs9628013858:24,184,080G/Tlikely benign
rs5555777128:24,184,134G/Auncertain significance
rs1397369038:24,184,140G/Alikely benign
rs7707080548:24,187,534A/Tuncertain significance
rs13245601188:24,187,549G/Cuncertain significance
rs5683155858:24,188,668A/Guncertain significance
rs7604450618:24,188,669T/Clikely benign
rs18133094388:24,188,677C/Tuncertain significance
rs1998917078:24,188,685A/Guncertain significance
rs13389095798:24,188,695G/Tuncertain significance
rs1425858768:24,188,832A/Cuncertain significance
rs7624847408:24,190,179A/Guncertain significance
rs24871164998:24,190,207G/Auncertain significance
rs3770022728:24,190,222C/Glikely benign
rs7642925848:24,190,225T/Guncertain significance
rs7464051628:24,190,249G/Tuncertain significance
rs1502396638:24,193,039T/Clikely benign
rs7685685058:24,193,105G/Auncertain significance
rs13662335638:24,193,152C/Tuncertain significance
rs24872308858:24,196,993G/Tuncertain significance
rs7495703878:24,196,994A/Guncertain significance
rs7663247888:24,197,006A/Guncertain significance
rs1916583458:24,197,035G/Tuncertain significance
rs2016437978:24,199,149C/Gaffects
rs1454537858:24,199,150G/Alikely benign
rs18147868248:24,199,208C/Auncertain significance
rs9855781688:24,201,030T/Guncertain significance
rs7542741128:24,201,070G/Alikely benign
rs15857182348:24,201,071A/Guncertain significance
rs7687840908:24,201,088G/Auncertain significance
rs2003466958:24,207,409A/Glikely benign
rs12675502038:24,207,464A/Glikely benign
rs5563172878:24,208,746C/Guncertain significance
rs24874198218:24,209,502G/Auncertain significance
rs2022420228:24,209,546A/Guncertain significance
rs1390996958:24,211,307C/Tlikely benign
rs18165326828:24,211,912G/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.