ADAM32
ADAM metallopeptidase domain 32
Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Known Variants48 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs892274949 | 8:38,965,314 | T/C | — | uncertain significance |
| rs372433561 | 8:38,975,631 | G/A | — | likely benign |
| rs201616533 | 8:38,994,186 | C/G | — | uncertain significance |
| rs201047294 | 8:38,994,223 | G/A | — | likely benign |
| rs774129995 | 8:39,008,900 | A/G | — | uncertain significance |
| rs2536607815 | 8:39,009,002 | G/A | — | uncertain significance |
| rs79341048 | 8:39,013,720 | C/T | downstream gene variant | — |
| rs1585426700 | 8:39,018,452 | C/A | — | uncertain significance |
| rs2536654661 | 8:39,018,468 | T/C | — | uncertain significance |
| rs201473947 | 8:39,018,470 | G/A | — | uncertain significance |
| rs370655802 | 8:39,018,483 | T/C | — | uncertain significance |
| rs1804724461 | 8:39,022,317 | C/G | — | uncertain significance |
| rs375823664 | 8:39,022,325 | G/A | — | likely benign |
| rs1804725755 | 8:39,022,332 | A/T | — | uncertain significance |
| rs373210270 | 8:39,022,708 | C/A | — | uncertain significance |
| rs1224158416 | 8:39,027,473 | C/T | — | uncertain significance |
| rs199865553 | 8:39,027,494 | G/A | — | likely benign |
| rs201567035 | 8:39,044,499 | A/G | — | uncertain significance |
| rs61753544 | 8:39,068,684 | T/A | — | likely benign |
| rs757601611 | 8:39,068,695 | G/A | — | uncertain significance |
| rs747125299 | 8:39,068,740 | A/G | — | likely benign |
| rs997357718 | 8:39,068,784 | C/G | — | uncertain significance |
| rs2536912982 | 8:39,068,836 | C/T | — | uncertain significance |
| rs369153366 | 8:39,079,211 | A/G | — | likely benign |
| rs143711220 | 8:39,080,574 | G/A | — | uncertain significance |
| rs370420091 | 8:39,080,595 | C/T | — | uncertain significance |
| rs1809100978 | 8:39,080,673 | C/T | — | uncertain significance |
| rs762485084 | 8:39,080,734 | G/A | — | uncertain significance |
| rs1809768001 | 8:39,089,552 | G/A | — | likely benign |
| rs1289948477 | 8:39,089,561 | C/T | — | uncertain significance |
| rs1293764996 | 8:39,091,439 | A/C | — | uncertain significance |
| rs1809924811 | 8:39,091,486 | A/G | — | uncertain significance |
| rs375936377 | 8:39,091,503 | G/A | — | uncertain significance |
| rs1809934596 | 8:39,091,549 | C/G | — | uncertain significance |
| rs2537038719 | 8:39,091,572 | A/G | — | uncertain significance |
| rs1241069855 | 8:39,091,594 | T/C | — | likely benign |
| rs142346085 | 8:39,103,645 | C/T | — | uncertain significance |
| rs745370857 | 8:39,103,680 | C/T | — | uncertain significance |
| rs777261468 | 8:39,111,982 | C/A | — | uncertain significance |
| rs751571313 | 8:39,112,014 | A/G | — | uncertain significance |
| rs371668554 | 8:39,112,015 | T/C | — | uncertain significance |
| rs2537146748 | 8:39,112,026 | G/C | — | uncertain significance |
| rs201527858 | 8:39,114,777 | A/G | — | likely benign |
| rs772218233 | 8:39,114,795 | G/A | — | uncertain significance |
| rs199764156 | 8:39,114,861 | G/A | — | uncertain significance |
| rs187557084 | 8:39,138,304 | T/C | intron variant | — |
| rs376216404 | 8:39,138,655 | A/G | — | likely benign |
| rs377111064 | 8:39,141,110 | A/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.