ADAMTS10

ADAM metallopeptidase with thrombospondin type 1 motif 10

Summary

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Known Variants742 total

rsidPosition (GRCh37)AllelesClassClinVar
rs18720107419:8,645,147G/A—uncertain significance
rs204232541919:8,645,199G/T—uncertain significance
rs142678625919:8,645,214G/T—uncertain significance
rs55547185219:8,645,328C/G—benign
rs138583791919:8,645,330C/A—uncertain significance
rs11602409519:8,645,349T/C—benign
rs88605470719:8,645,366G/A—uncertain significance
rs14152384919:8,645,421C/T—uncertain significance
rs130237593619:8,645,447T/A—uncertain significance
rs88605470819:8,645,455G/A—uncertain significance
rs104579609319:8,645,466T/C—uncertain significance
rs7449850619:8,645,518C/T—likely benign
rs147105853119:8,645,568G/A—uncertain significance
rs7923837519:8,645,606C/T—likely benign
rs204233274619:8,645,620C/T—uncertain significance
rs91015620319:8,645,631C/T—uncertain significance
rs88605470919:8,645,696C/A—uncertain significance
rs90591321719:8,645,730T/C—uncertain significance
rs78234803319:8,645,741A/G—uncertain significance
rs13792808319:8,645,757C/T—likely benign
rs78242701619:8,645,783G/A—likely benign
rs725229919:8,645,786A/Cmissense variantbenign
rs78220103119:8,645,789G/A—likely benign
rs251255741319:8,645,807C/G—uncertain significance
rs78241209519:8,645,812G/T—uncertain significance
rs78194090019:8,645,819G/C—likely benign
rs78205355619:8,645,821C/T—uncertain significance
rs204233740519:8,645,825G/T—uncertain significance
rs20063952919:8,645,827T/C—uncertain significance
rs204233770419:8,645,845G/C—uncertain significance
rs251255773419:8,645,855G/A—likely benign
rs136555713119:8,645,868T/C—uncertain significance
rs160008763219:8,645,873C/G—likely benign
rs78281132919:8,645,891G/A—benign
rs155573568619:8,645,893G/A—likely benign
rs155573568819:8,645,894G/C—likely benign
rs20107459319:8,645,896C/G—likely benign
rs147667003219:8,645,897G/A—likely benign
rs78188864819:8,645,898G/C—likely benign
rs78214768719:8,645,899G/A—likely benign
rs78269571919:8,645,901G/A—likely benign
rs124493746519:8,645,905G/C—likely benign
rs79704164719:8,646,015T/C—benign
rs7967460919:8,649,527G/A—benign
rs88605471019:8,649,766G/A—conflicting classifications of pathogenicity
rs204240241719:8,649,786G/T—likely benign
rs8004665319:8,649,788C/T—likely benign
rs78231730919:8,649,793C/A—uncertain significance
rs53024430819:8,649,799G/T—uncertain significance
rs214603776119:8,649,804G/T—uncertain significance
rs99252995719:8,649,809C/G—uncertain significance
rs251257137019:8,649,812A/T—uncertain significance
rs251257140819:8,649,816G/A—likely benign
rs251257143019:8,649,821C/G—uncertain significance
rs88605471119:8,649,822A/G—uncertain significance
rs251257148919:8,649,827G/A—pathogenic
rs156839118419:8,649,828C/T—likely benign
rs204240329619:8,649,831C/T—likely benign
rs91667784619:8,649,832G/C—uncertain significance
rs141164715519:8,649,840C/A—likely benign
rs96947339119:8,649,843C/T—likely benign
rs116857579619:8,649,848G/A—likely benign
rs142930787119:8,649,858G/A—likely benign
rs78203030519:8,649,861C/T—likely benign
rs56699932119:8,649,865T/G—uncertain significance
rs155573645019:8,649,867C/A—likely benign
rs155573645519:8,649,869A/T—uncertain significance
rs119578440119:8,649,873C/G—uncertain significance
rs251257181019:8,649,876G/T—likely benign
rs1040595619:8,649,879C/T—likely benign
rs124655570519:8,649,884G/A—uncertain significance
rs144007251019:8,649,889G/T—uncertain significance
rs204240498619:8,649,896G/T—uncertain significance
rs155573646719:8,649,897C/T—likely benign
rs133957217719:8,649,898A/C—likely pathogenic
rs78191600619:8,649,900C/T—likely benign
rs251257196919:8,649,902A/G—uncertain significance
rs204240540319:8,649,915C/G—likely benign
rs214603826419:8,649,921G/C—likely benign
rs155573649719:8,649,930T/C—likely benign
rs214603830819:8,649,936G/A—likely benign
rs78209648119:8,649,943G/A—likely benign
rs75909897919:8,649,946G/A—conflicting classifications of pathogenicity
rs136883218519:8,649,948G/T—likely benign
rs90015425419:8,650,000G/T—likely benign
rs56916875019:8,650,034C/T—likely benign
rs204240816219:8,650,041C/T—uncertain significance
rs104883918319:8,650,047G/A—uncertain significance
rs155573657719:8,650,052G/A—likely benign
rs204240855719:8,650,056C/T—uncertain significance
rs115905972119:8,650,072G/A—likely pathogenic
rs147190485819:8,650,075T/A—uncertain significance
rs53809788619:8,650,076G/C—benign
rs155573659719:8,650,078T/C—uncertain significance
rs147223408519:8,650,082C/A—likely benign
rs204240930519:8,650,097G/A—likely benign
rs155573660619:8,650,110G/T—uncertain significance
rs78184323819:8,650,115G/A—likely benign
rs120667378819:8,650,120G/C—uncertain significance
rs89670229319:8,650,121C/T—likely benign

Showing 100 of 742 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.