ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Known Variants74 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2541520331 | 11:130,318,991 | C/G | — | pathogenic |
| rs767814936 | 11:130,319,004 | G/A | — | uncertain significance |
| rs1433313938 | 11:130,319,011 | C/A | — | uncertain significance |
| rs758180309 | 11:130,319,046 | T/C | — | uncertain significance |
| rs543981274 | 11:130,319,068 | A/G | — | uncertain significance |
| rs758649194 | 11:130,319,112 | G/C | — | uncertain significance |
| rs1565389380 | 11:130,319,118 | C/G | — | uncertain significance |
| rs1364496175 | 11:130,319,119 | T/A | — | uncertain significance |
| rs148309073 | 11:130,319,202 | G/C | — | uncertain significance |
| rs1261325377 | 11:130,319,415 | G/A | — | uncertain significance |
| rs1937915850 | 11:130,319,439 | T/A | — | uncertain significance |
| rs143601958 | 11:130,319,515 | T/A | — | uncertain significance |
| rs367694277 | 11:130,319,518 | C/G | — | uncertain significance |
| rs1315210313 | 11:130,319,521 | G/A | — | uncertain significance |
| rs61753090 | 11:130,319,571 | G/A | — | benign |
| rs149703887 | 11:130,319,637 | A/G | — | uncertain significance |
| rs371415392 | 11:130,319,643 | C/T | — | uncertain significance |
| rs543059162 | 11:130,319,790 | G/A | — | uncertain significance |
| rs181619709 | 11:130,320,518 | G/A | intron variant | — |
| rs184041499 | 11:130,331,384 | G/A | — | uncertain significance |
| rs1175598296 | 11:130,331,996 | A/G | — | uncertain significance |
| rs772548681 | 11:130,332,011 | G/A | — | uncertain significance |
| rs769395017 | 11:130,332,066 | C/T | — | uncertain significance |
| rs958317094 | 11:130,332,071 | C/G | — | uncertain significance |
| rs760835453 | 11:130,332,083 | G/T | — | uncertain significance |
| rs531491655 | 11:130,332,104 | G/A | — | uncertain significance |
| rs116897071 | 11:130,332,457 | T/C | missense variant | — |
| rs535808287 | 11:130,332,493 | G/C | — | uncertain significance |
| rs2541532001 | 11:130,332,527 | G/A | — | uncertain significance |
| rs189029139 | 11:130,332,581 | G/A | — | uncertain significance |
| rs201611580 | 11:130,332,640 | G/A | — | likely benign |
| rs1361620775 | 11:130,332,646 | G/A | — | uncertain significance |
| rs755957210 | 11:130,332,653 | G/A | — | uncertain significance |
| rs780111148 | 11:130,339,175 | A/G | — | uncertain significance |
| rs1465170396 | 11:130,339,203 | G/A | — | uncertain significance |
| rs149341964 | 11:130,339,220 | G/A | — | likely benign |
| rs763974494 | 11:130,339,248 | A/C | — | uncertain significance |
| rs755197416 | 11:130,339,265 | G/A | — | uncertain significance |
| rs2541541332 | 11:130,340,838 | G/A | — | uncertain significance |
| rs780632888 | 11:130,340,863 | A/G | — | uncertain significance |
| rs373000118 | 11:130,340,880 | C/T | — | uncertain significance |
| rs760756603 | 11:130,340,919 | G/A | — | uncertain significance |
| rs900442449 | 11:130,341,101 | A/G | — | pathogenic |
| rs886112446 | 11:130,341,134 | C/T | — | uncertain significance |
| rs763095301 | 11:130,341,137 | C/T | — | uncertain significance |
| rs774915694 | 11:130,341,142 | G/A | — | uncertain significance |
| rs368055583 | 11:130,341,163 | A/C | — | uncertain significance |
| rs199538468 | 11:130,341,170 | C/G | — | uncertain significance |
| rs538068444 | 11:130,341,184 | A/C | — | uncertain significance |
| rs542356137 | 11:130,341,191 | G/T | — | uncertain significance |
| rs1198595122 | 11:130,341,226 | G/T | — | uncertain significance |
| rs749462367 | 11:130,341,275 | C/G | — | uncertain significance |
| rs2541543823 | 11:130,342,974 | C/T | — | uncertain significance |
| rs61746092 | 11:130,343,023 | C/T | — | benign |
| rs200840813 | 11:130,343,135 | C/T | — | uncertain significance |
| rs61753091 | 11:130,343,143 | C/T | — | likely benign |
| rs754451064 | 11:130,343,144 | G/A | — | pathogenic |
| rs757688845 | 11:130,343,148 | C/T | — | uncertain significance |
| rs776537988 | 11:130,343,172 | A/G | — | uncertain significance |
| rs759711415 | 11:130,343,180 | C/T | — | uncertain significance |
| rs144558172 | 11:130,343,357 | G/A | — | uncertain significance |
| rs200241034 | 11:130,343,367 | C/T | — | uncertain significance |
| rs61757474 | 11:130,343,368 | G/A | — | benign |
| rs1332554850 | 11:130,343,432 | A/G | — | likely benign |
| rs560827134 | 11:130,343,462 | C/T | — | uncertain significance |
| rs750323599 | 11:130,343,481 | G/A | — | uncertain significance |
| rs757213675 | 11:130,343,510 | C/T | — | uncertain significance |
| rs762946720 | 11:130,343,529 | C/T | — | uncertain significance |
| rs375061494 | 11:130,343,558 | C/G | — | uncertain significance |
| rs2541545118 | 11:130,343,578 | C/G | — | likely pathogenic |
| rs766451560 | 11:130,343,633 | G/A | — | uncertain significance |
| rs61743323 | 11:130,343,640 | G/A | — | uncertain significance |
| rs1242266641 | 11:130,343,696 | T/G | — | uncertain significance |
| rs61744317 | 11:130,343,702 | C/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.