ADCY10

adenylate cyclase 10

Summary

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

Known Variants443 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs17482467	1:167,778,705	C/A	—	benign
rs3213588	1:167,778,843	G/A	—	benign
rs112911097	1:167,778,926	T/C	—	uncertain significance
rs2524815082	1:167,778,931	A/C	—	uncertain significance
rs201892899	1:167,778,932	C/T	—	uncertain significance
rs146952021	1:167,778,933	G/A	—	likely benign
rs1662078067	1:167,778,934	G/A	—	likely benign
rs141927353	1:167,778,979	T/A	—	uncertain significance
rs755426228	1:167,778,985	C/G	—	uncertain significance
rs201210676	1:167,778,994	A/G	—	uncertain significance
rs59725214	1:167,778,996	A/G	—	likely benign
rs148028125	1:167,779,027	G/A	—	benign
rs772188446	1:167,779,033	A/G	—	uncertain significance
rs1186683204	1:167,779,035	C/G	—	uncertain significance
rs2524817356	1:167,779,067	A/C	—	uncertain significance
rs74486783	1:167,779,865	C/A	—	benign
rs1198602139	1:167,779,964	T/A	—	uncertain significance
rs61743401	1:167,779,982	A/G	—	likely benign
rs1332731500	1:167,779,986	C/A	—	uncertain significance
rs748002734	1:167,780,005	G/A	—	uncertain significance
rs1662151205	1:167,780,008	T/C	—	uncertain significance
rs150827904	1:167,780,018	G/A	—	uncertain significance
rs1662155517	1:167,780,060	C/T	—	uncertain significance
rs117021474	1:167,780,071	C/T	—	benign
rs144839993	1:167,780,075	C/T	—	uncertain significance
rs186485513	1:167,780,086	A/G	—	uncertain significance
rs1297291684	1:167,780,102	G/T	—	uncertain significance
rs114703390	1:167,780,103	G/C	—	conflicting classifications of pathogenicity
rs200833497	1:167,780,129	G/C	—	uncertain significance
rs11586850	1:167,787,032	G/A	—	benign
rs12060498	1:167,787,265	C/T	—	benign
rs75209820	1:167,787,307	C/T	—	benign
rs745840397	1:167,787,348	A/T	—	uncertain significance
rs763430872	1:167,787,351	G/C	—	uncertain significance
rs1662641163	1:167,787,354	C/A	—	pathogenic
rs1377866855	1:167,787,362	T/C	—	uncertain significance
rs199702241	1:167,787,368	T/C	—	uncertain significance
rs1662645180	1:167,787,393	T/C	—	uncertain significance
rs61745242	1:167,787,403	T/A	—	likely benign
rs200667417	1:167,787,408	C/T	—	uncertain significance
rs376100922	1:167,787,409	G/A	—	likely benign
rs2101843895	1:167,787,414	A/G	—	uncertain significance
rs61745244	1:167,787,415	G/A	—	likely benign
rs201804890	1:167,787,458	C/G	—	conflicting classifications of pathogenicity
rs200807095	1:167,787,475	A/T	—	uncertain significance
rs41270737	1:167,787,479	C/T	—	likely benign
rs1662653345	1:167,787,500	G/A	—	uncertain significance
rs775686417	1:167,787,505	C/G	—	uncertain significance
rs1662944955	1:167,791,300	A/G	—	likely benign
rs755582452	1:167,791,304	T/A	—	uncertain significance
rs375622466	1:167,791,316	A/T	—	uncertain significance
rs758859163	1:167,791,321	G/T	—	uncertain significance
rs61737676	1:167,791,328	T/C	—	likely benign
rs148081594	1:167,791,336	G/A	—	likely benign
rs774417777	1:167,791,373	A/G	—	uncertain significance
rs1662951098	1:167,791,377	A/C	—	uncertain significance
rs34888342	1:167,792,050	C/T	—	benign
rs2269673	1:167,792,079	T/G	—	benign
rs202015026	1:167,792,229	C/T	—	likely benign
rs767976390	1:167,792,236	C/T	—	likely benign
rs996858935	1:167,792,245	C/T	—	likely pathogenic
rs371824241	1:167,792,267	A/G	—	likely benign
rs1663013543	1:167,792,278	T/C	—	uncertain significance
rs766688731	1:167,792,332	C/T	—	uncertain significance
rs200703036	1:167,792,333	G/A	—	uncertain significance
rs2524919986	1:167,792,336	C/T	—	uncertain significance
rs73039538	1:167,792,339	G/A	—	likely benign
rs148814511	1:167,792,342	C/A	—	likely benign
rs201556412	1:167,792,355	C/A	—	likely benign
rs72697797	1:167,792,356	A/G	—	likely benign
rs200816878	1:167,792,359	T/C	—	uncertain significance
rs769327075	1:167,792,381	G/A	—	likely benign
rs2269674	1:167,792,617	C/T	—	benign
rs1242661790	1:167,792,662	C/A	—	benign
rs1476073	1:167,793,477	C/T	—	benign
rs113582348	1:167,793,505	G/A	—	benign
rs1476074	1:167,793,670	T/C	—	benign
rs2524933602	1:167,793,712	A/G	—	likely pathogenic
rs1420501321	1:167,793,717	C/T	—	likely benign
rs570838010	1:167,793,719	G/A	—	likely benign
rs748895833	1:167,793,732	C/T	—	uncertain significance
rs535006366	1:167,793,736	T/G	—	likely benign
rs146725782	1:167,793,766	G/A	—	pathogenic
rs7531790	1:167,793,767	G/A	—	benign
rs574701020	1:167,793,768	T/C	—	uncertain significance
rs1663137907	1:167,793,805	G/A	—	pathogenic
rs777261057	1:167,793,872	G/C	—	likely benign
rs781107148	1:167,793,897	A/G	—	uncertain significance
rs751688762	1:167,793,913	G/T	—	uncertain significance
rs755039746	1:167,793,923	G/A	—	likely benign
rs2524936517	1:167,793,946	C/T	—	uncertain significance
rs745426103	1:167,793,969	A/G	—	likely benign
rs564897812	1:167,793,980	T/G	—	conflicting classifications of pathogenicity
rs2524937155	1:167,793,984	A/C	—	uncertain significance
rs771201791	1:167,793,988	G/A	—	uncertain significance
rs1185648254	1:167,793,989	G/A	—	likely benign
rs774553482	1:167,794,004	C/T	—	likely benign
rs1043496853	1:167,794,011	G/T	—	uncertain significance
rs199699821	1:167,794,015	T/C	—	uncertain significance
rs865913887	1:167,794,021	C/A	—	pathogenic

Showing 100 of 443 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.