ADGRB2

adhesion G protein-coupled receptor B2

Summary

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Known Variants250 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs147230286	1:32,193,044	C/T	—	likely benign
rs74431877	1:32,193,049	G/A	—	benign
rs2523448763	1:32,193,055	T/C	—	uncertain significance
rs149701008	1:32,193,063	C/T	—	benign
rs139337826	1:32,193,094	C/T	—	uncertain significance
rs747810006	1:32,193,100	C/T	—	uncertain significance
rs2148863011	1:32,193,108	G/T	—	likely benign
rs769490381	1:32,193,110	G/C	—	uncertain significance
rs375391528	1:32,193,160	C/T	—	uncertain significance
rs544570941	1:32,193,164	G/A	—	uncertain significance
rs41263977	1:32,193,185	G/A	—	benign
rs376877976	1:32,193,218	G/A	—	likely benign
rs201452112	1:32,193,219	C/T	—	likely benign
rs748198072	1:32,193,625	C/T	—	uncertain significance
rs771122565	1:32,193,635	G/A	—	likely benign
rs768031611	1:32,193,639	C/T	—	uncertain significance
rs576638646	1:32,193,643	C/T	—	uncertain significance
rs146421594	1:32,193,644	G/C	—	benign
rs1127100	1:32,193,647	C/T	—	benign
rs140855923	1:32,193,656	C/T	—	likely benign
rs138967196	1:32,193,657	G/A	—	likely benign
rs2523476603	1:32,193,682	T/G	—	likely benign
rs141155138	1:32,193,699	C/T	—	benign
rs199639016	1:32,193,767	C/T	—	likely benign
rs188544949	1:32,193,773	G/A	—	benign
rs376584625	1:32,193,776	C/G	—	likely benign
rs77499146	1:32,193,790	G/A	—	benign
rs779141200	1:32,193,808	C/A	—	uncertain significance
rs1341588850	1:32,193,837	C/T	—	likely benign
rs142991391	1:32,193,859	C/T	—	uncertain significance
rs201415816	1:32,193,866	G/A	—	uncertain significance
rs540992823	1:32,194,189	T/C	—	likely benign
rs778361520	1:32,194,222	G/A	—	likely pathogenic
rs765198928	1:32,196,454	G/A	—	uncertain significance
rs1451727282	1:32,196,459	C/T	—	uncertain significance
rs756351722	1:32,196,487	C/T	—	uncertain significance
rs754299694	1:32,196,493	G/A	—	uncertain significance
rs779585459	1:32,196,500	C/T	—	likely benign
rs41311144	1:32,196,506	C/T	—	benign
rs145273184	1:32,196,549	G/A	—	uncertain significance
rs921117176	1:32,196,580	C/T	—	uncertain significance
rs61744251	1:32,196,584	C/T	—	benign
rs2523570666	1:32,196,631	G/A	—	uncertain significance
rs909001	1:32,196,647	C/G	—	likely benign
rs61744431	1:32,196,668	C/G	—	benign
rs751030662	1:32,196,688	C/T	—	conflicting classifications of pathogenicity
rs369677687	1:32,196,714	C/T	—	uncertain significance
rs10914473	1:32,196,889	G/A	—	benign
rs368610104	1:32,196,916	G/A	—	uncertain significance
rs535834452	1:32,196,922	C/T	—	uncertain significance
rs748198208	1:32,196,964	G/A	—	uncertain significance
rs771249644	1:32,196,989	C/T	—	likely benign
rs2523585073	1:32,196,992	G/T	—	uncertain significance
rs774678243	1:32,196,995	G/A	—	likely benign
rs377337021	1:32,197,039	G/C	—	likely benign
rs146433313	1:32,197,705	G/A	—	benign
rs370267169	1:32,198,132	G/T	—	uncertain significance
rs758687411	1:32,198,133	C/A	—	likely benign
rs140777869	1:32,198,136	G/A	—	benign
rs61742965	1:32,198,175	C/T	—	benign
rs148580797	1:32,198,577	C/T	—	uncertain significance
rs201556659	1:32,198,619	G/A	—	uncertain significance
rs766443769	1:32,198,620	C/T	—	uncertain significance
rs771239503	1:32,198,621	G/A	—	likely benign
rs2523644082	1:32,198,628	A/G	—	uncertain significance
rs368713364	1:32,198,683	C/T	—	uncertain significance
rs140842802	1:32,198,684	G/A	—	likely benign
rs936804181	1:32,198,699	G/A	—	likely benign
rs2523648483	1:32,198,721	A/G	—	uncertain significance
rs1369322828	1:32,200,829	G/A	—	uncertain significance
rs552707221	1:32,200,863	C/G	—	uncertain significance
rs781131307	1:32,201,163	C/G	—	likely benign
rs2271930	1:32,201,169	C/T	—	benign
rs186740027	1:32,201,170	C/G	—	benign
rs370953719	1:32,201,171	C/T	—	likely benign
rs12409382	1:32,201,175	C/G	—	uncertain significance
rs199560963	1:32,201,182	C/T	—	uncertain significance
rs146525691	1:32,201,183	G/A	—	benign
rs759075913	1:32,201,206	C/T	—	uncertain significance
rs902839902	1:32,201,220	C/T	—	uncertain significance
rs760443752	1:32,201,221	G/A	—	uncertain significance
rs1645561417	1:32,201,225	C/T	—	uncertain significance
rs149102471	1:32,201,242	C/T	—	uncertain significance
rs1444024356	1:32,201,254	T/C	—	uncertain significance
rs375068549	1:32,201,280	A/T	—	likely benign
rs113133865	1:32,201,417	C/T	—	benign
rs142973128	1:32,201,439	C/T	—	likely benign
rs113351457	1:32,201,473	G/A	—	benign
rs201681314	1:32,201,502	G/C	—	benign
rs759449062	1:32,201,946	G/A	—	uncertain significance
rs753970609	1:32,201,969	G/A	—	likely benign
rs200822256	1:32,201,987	C/T	—	likely benign
rs2523781165	1:32,202,007	T/C	—	likely benign
rs1437351799	1:32,202,216	G/A	—	uncertain significance
rs751936334	1:32,202,227	A/G	—	uncertain significance
rs755968306	1:32,202,279	A/C	—	uncertain significance
rs2148922907	1:32,202,304	A/C	—	likely benign
rs376148936	1:32,202,321	C/T	—	uncertain significance
rs775422771	1:32,202,322	G/A	—	likely benign
rs370784373	1:32,202,341	T/C	—	likely benign

Showing 100 of 250 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.