ADGRG4
adhesion G protein-coupled receptor G4
Summary
This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
Known Variants158 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs186214790 | X:135,404,948 | C/A | — | uncertain significance |
| rs1395081404 | X:135,404,996 | A/C | — | likely benign |
| rs931440644 | X:135,405,006 | A/T | — | uncertain significance |
| rs775947024 | X:135,405,120 | G/A | — | uncertain significance |
| rs374820774 | X:135,405,197 | C/T | — | uncertain significance |
| rs2521620069 | X:135,405,333 | G/A | — | uncertain significance |
| rs779610287 | X:135,405,425 | C/T | — | uncertain significance |
| rs763907204 | X:135,405,449 | G/A | — | uncertain significance |
| rs746554720 | X:135,405,500 | G/A | — | uncertain significance |
| rs145079154 | X:135,405,527 | A/G | — | uncertain significance |
| rs138853777 | X:135,405,546 | G/A | — | uncertain significance |
| rs747347620 | X:135,426,623 | C/A | — | likely benign |
| rs201343525 | X:135,426,649 | A/G | — | uncertain significance |
| rs2074998620 | X:135,426,659 | A/G | — | uncertain significance |
| rs1238761140 | X:135,426,701 | C/G | — | uncertain significance |
| rs148591462 | X:135,426,718 | T/A | — | uncertain significance |
| rs764915195 | X:135,426,812 | A/T | — | uncertain significance |
| rs1220805632 | X:135,426,863 | T/C | — | uncertain significance |
| rs201466383 | X:135,426,893 | C/A | — | uncertain significance |
| rs778665341 | X:135,427,049 | C/T | — | uncertain significance |
| rs774049812 | X:135,427,082 | C/A | — | uncertain significance |
| rs140366775 | X:135,427,147 | C/T | — | uncertain significance |
| rs145542316 | X:135,427,285 | A/C | — | uncertain significance |
| rs772818899 | X:135,427,360 | A/G | — | likely benign |
| rs1294975499 | X:135,427,471 | T/C | — | uncertain significance |
| rs199858400 | X:135,427,531 | A/T | — | uncertain significance |
| rs758159588 | X:135,427,558 | T/C | — | uncertain significance |
| rs140316522 | X:135,427,575 | T/A | — | uncertain significance |
| rs151008495 | X:135,427,606 | C/T | — | uncertain significance |
| rs773816253 | X:135,427,609 | A/G | — | uncertain significance |
| rs373273371 | X:135,427,636 | G/A | — | uncertain significance |
| rs138876740 | X:135,427,678 | G/A | — | uncertain significance |
| rs2521689328 | X:135,427,719 | C/T | — | likely benign |
| rs774065130 | X:135,427,775 | G/A | — | uncertain significance |
| rs765869573 | X:135,427,813 | T/C | — | uncertain significance |
| rs753354724 | X:135,427,814 | C/T | — | uncertain significance |
| rs1246614990 | X:135,427,820 | A/G | — | conflicting classifications of pathogenicity |
| rs41299092 | X:135,427,828 | A/G | — | conflicting classifications of pathogenicity |
| rs374256351 | X:135,427,887 | C/T | — | likely benign |
| rs765083628 | X:135,427,919 | C/T | — | uncertain significance |
| rs866844807 | X:135,427,990 | C/A | — | likely benign |
| rs2075013412 | X:135,428,086 | A/G | — | uncertain significance |
| rs2148465729 | X:135,428,111 | C/A | — | uncertain significance |
| rs747025842 | X:135,428,254 | C/T | — | uncertain significance |
| rs751152004 | X:135,428,257 | A/G | — | uncertain significance |
| rs2521693724 | X:135,428,369 | T/C | — | uncertain significance |
| rs148957422 | X:135,428,452 | C/T | — | uncertain significance |
| rs2075017540 | X:135,428,563 | A/G | — | uncertain significance |
| rs2521695175 | X:135,428,656 | T/C | — | uncertain significance |
| rs2521695594 | X:135,428,729 | C/A | — | uncertain significance |
| rs139374709 | X:135,428,755 | G/A | — | uncertain significance |
| rs147143419 | X:135,428,828 | C/T | — | likely benign |
| rs770074026 | X:135,428,888 | C/T | — | uncertain significance |
| rs760794810 | X:135,429,110 | G/A | — | uncertain significance |
| rs755135197 | X:135,429,122 | G/A | — | likely benign |
| rs990265087 | X:135,429,169 | G/A | — | uncertain significance |
| rs139973264 | X:135,429,242 | C/T | — | uncertain significance |
| rs748422787 | X:135,429,332 | C/T | — | likely benign |
| rs762749140 | X:135,429,359 | C/T | — | likely benign |
| rs763923949 | X:135,429,360 | G/A | — | likely benign |
| rs375612242 | X:135,429,438 | C/A | — | uncertain significance |
| rs780531042 | X:135,429,556 | A/G | — | uncertain significance |
| rs140460718 | X:135,429,562 | T/C | — | likely benign |
| rs1222619561 | X:135,429,572 | C/T | — | uncertain significance |
| rs377028258 | X:135,429,577 | C/T | — | uncertain significance |
| rs748033473 | X:135,429,662 | G/T | — | uncertain significance |
| rs2521702699 | X:135,429,829 | A/C | — | uncertain significance |
| rs2521704080 | X:135,430,048 | G/A | — | likely benign |
| rs200964504 | X:135,430,118 | C/A | — | uncertain significance |
| rs2521704499 | X:135,430,121 | C/T | — | uncertain significance |
| rs183614997 | X:135,430,134 | A/G | — | benign |
| rs778459520 | X:135,430,157 | A/G | — | uncertain significance |
| rs2521705358 | X:135,430,270 | T/C | — | uncertain significance |
| rs780768816 | X:135,430,342 | A/G | — | uncertain significance |
| rs763125855 | X:135,430,375 | A/T | — | uncertain significance |
| rs143353057 | X:135,430,504 | T/A | — | likely benign |
| rs2521707292 | X:135,430,592 | C/T | — | uncertain significance |
| rs2521707404 | X:135,430,616 | G/A | — | uncertain significance |
| rs781722775 | X:135,430,631 | C/G | — | uncertain significance |
| rs2521707714 | X:135,430,675 | C/G | — | uncertain significance |
| rs1455373624 | X:135,430,718 | C/T | — | uncertain significance |
| rs146283448 | X:135,430,793 | C/T | — | uncertain significance |
| rs200165046 | X:135,430,879 | G/T | — | uncertain significance |
| rs2521708905 | X:135,430,910 | C/T | — | uncertain significance |
| rs766927591 | X:135,431,023 | G/A | — | uncertain significance |
| rs772858032 | X:135,431,032 | A/G | — | uncertain significance |
| rs752988298 | X:135,431,082 | T/A | — | uncertain significance |
| rs2521710002 | X:135,431,122 | C/T | — | likely benign |
| rs775341951 | X:135,431,252 | G/A | — | uncertain significance |
| rs2521711049 | X:135,431,284 | T/G | — | uncertain significance |
| rs773478883 | X:135,431,440 | C/G | — | uncertain significance |
| rs374459154 | X:135,431,465 | G/A | — | likely benign |
| rs779581627 | X:135,431,467 | A/G | — | uncertain significance |
| rs547324925 | X:135,431,776 | G/A | — | likely benign |
| rs144593814 | X:135,431,924 | C/T | — | likely benign |
| rs756479171 | X:135,431,988 | A/G | — | likely benign |
| rs768075442 | X:135,431,992 | C/G | — | uncertain significance |
| rs145577664 | X:135,432,005 | T/G | — | uncertain significance |
| rs181025159 | X:135,432,034 | A/G | — | uncertain significance |
| rs766908414 | X:135,432,178 | C/T | — | uncertain significance |
Showing 100 of 158 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.