ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
Summary
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1139490 | 4:100,045,141 | C/T | 3 prime UTR variant | — |
| rs1042364 | 4:100,045,574 | T/A | — | — |
| rs747209153 | 4:100,045,612 | C/T | — | uncertain significance |
| rs748159787 | 4:100,047,790 | A/G | — | uncertain significance |
| rs2529856931 | 4:100,047,821 | G/C | — | uncertain significance |
| rs10009145 | 4:100,047,929 | G/A | intron variant | — |
| rs29001219 | 4:100,048,386 | C/A | — | uncertain significance |
| rs781087602 | 4:100,048,387 | G/A | — | uncertain significance |
| rs1126671 | 4:100,048,414 | T/G | missense variant | — |
| rs367861880 | 4:100,048,446 | A/G | — | uncertain significance |
| rs4699710 | 4:100,051,819 | C/G | — | — |
| rs766382847 | 4:100,052,795 | A/G | — | uncertain significance |
| rs765110862 | 4:100,052,806 | T/C | — | uncertain significance |
| rs556499305 | 4:100,052,834 | C/T | — | uncertain significance |
| rs376782292 | 4:100,052,866 | A/G | — | uncertain significance |
| rs771009134 | 4:100,052,873 | C/A | — | uncertain significance |
| rs765165587 | 4:100,052,896 | C/T | — | uncertain significance |
| rs6848050 | 4:100,053,733 | T/A | — | — |
| rs6822348 | 4:100,053,894 | A/T | intron variant | — |
| rs7672728 | 4:100,055,173 | A/G | intron variant | — |
| rs7689753 | 4:100,055,575 | A/G | intron variant | — |
| rs4148887 | 4:100,055,862 | A/G | intron variant | — |
| rs3805322 | 4:100,056,998 | A/G | intron variant | — |
| rs1304838146 | 4:100,057,636 | G/A | — | uncertain significance |
| rs749168437 | 4:100,057,761 | G/C | — | uncertain significance |
| rs35229514 | 4:100,057,804 | T/G | — | uncertain significance |
| rs2529882477 | 4:100,060,287 | A/G | — | uncertain significance |
| rs13148577 | 4:100,060,836 | G/A | intron variant | — |
| rs376943095 | 4:100,062,694 | G/C | — | uncertain significance |
| rs766470523 | 4:100,062,701 | C/T | — | uncertain significance |
| rs756942645 | 4:100,062,739 | G/A | — | uncertain significance |
| rs745518809 | 4:100,062,748 | T/C | — | uncertain significance |
| rs572462879 | 4:100,062,754 | A/G | — | uncertain significance |
| rs748709323 | 4:100,062,755 | C/T | — | uncertain significance |
| rs201022290 | 4:100,062,770 | C/G | — | uncertain significance |
| rs6831352 | 4:100,063,525 | T/A | — | — |
| rs61754858 | 4:100,063,853 | T/C | — | uncertain significance |
| rs145793949 | 4:100,063,855 | G/A | — | uncertain significance |
| rs775749904 | 4:100,063,868 | C/T | — | uncertain significance |
| rs138623507 | 4:100,063,889 | G/C | — | uncertain significance |
| rs1465972449 | 4:100,063,907 | C/T | — | uncertain significance |
| rs1800759 | 4:100,065,509 | T/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.