ADH4

alcohol dehydrogenase 4 (class II), pi polypeptide

Summary

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Known Variants42 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11394904:100,045,141C/T3 prime UTR variant
rs10423644:100,045,574T/A
rs7472091534:100,045,612C/Tuncertain significance
rs7481597874:100,047,790A/Guncertain significance
rs25298569314:100,047,821G/Cuncertain significance
rs100091454:100,047,929G/Aintron variant
rs290012194:100,048,386C/Auncertain significance
rs7810876024:100,048,387G/Auncertain significance
rs11266714:100,048,414T/Gmissense variant
rs3678618804:100,048,446A/Guncertain significance
rs46997104:100,051,819C/G
rs7663828474:100,052,795A/Guncertain significance
rs7651108624:100,052,806T/Cuncertain significance
rs5564993054:100,052,834C/Tuncertain significance
rs3767822924:100,052,866A/Guncertain significance
rs7710091344:100,052,873C/Auncertain significance
rs7651655874:100,052,896C/Tuncertain significance
rs68480504:100,053,733T/A
rs68223484:100,053,894A/Tintron variant
rs76727284:100,055,173A/Gintron variant
rs76897534:100,055,575A/Gintron variant
rs41488874:100,055,862A/Gintron variant
rs38053224:100,056,998A/Gintron variant
rs13048381464:100,057,636G/Auncertain significance
rs7491684374:100,057,761G/Cuncertain significance
rs352295144:100,057,804T/Guncertain significance
rs25298824774:100,060,287A/Guncertain significance
rs131485774:100,060,836G/Aintron variant
rs3769430954:100,062,694G/Cuncertain significance
rs7664705234:100,062,701C/Tuncertain significance
rs7569426454:100,062,739G/Auncertain significance
rs7455188094:100,062,748T/Cuncertain significance
rs5724628794:100,062,754A/Guncertain significance
rs7487093234:100,062,755C/Tuncertain significance
rs2010222904:100,062,770C/Guncertain significance
rs68313524:100,063,525T/A
rs617548584:100,063,853T/Cuncertain significance
rs1457939494:100,063,855G/Auncertain significance
rs7757499044:100,063,868C/Tuncertain significance
rs1386235074:100,063,889G/Cuncertain significance
rs14659724494:100,063,907C/Tuncertain significance
rs18007594:100,065,509T/Gregulatory region variant

Gene information from NCBI Gene. Variant classifications from ClinVar.