AEN
apoptosis enhancing nuclease
Summary
Enables DNA exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs57192577 | 15:89,150,965 | T/C | upstream gene variant | — |
| rs2057850261 | 15:89,169,468 | G/T | — | uncertain significance |
| rs144659811 | 15:89,169,520 | G/A | — | uncertain significance |
| rs146703815 | 15:89,169,525 | A/G | — | uncertain significance |
| rs756247681 | 15:89,169,555 | C/T | — | uncertain significance |
| rs369860978 | 15:89,169,556 | G/A | — | uncertain significance |
| rs202093467 | 15:89,169,573 | G/T | — | uncertain significance |
| rs772435599 | 15:89,169,664 | A/T | — | uncertain significance |
| rs530223417 | 15:89,169,729 | C/T | — | uncertain significance |
| rs143920438 | 15:89,169,804 | C/T | — | uncertain significance |
| rs775685764 | 15:89,169,831 | C/T | — | uncertain significance |
| rs528215004 | 15:89,169,879 | A/C | — | uncertain significance |
| rs375287786 | 15:89,169,891 | A/T | — | uncertain significance |
| rs1309417704 | 15:89,169,897 | A/G | — | uncertain significance |
| rs368922473 | 15:89,172,518 | C/T | — | uncertain significance |
| rs1211503257 | 15:89,172,539 | G/A | — | uncertain significance |
| rs780362012 | 15:89,172,589 | G/C | — | uncertain significance |
| rs770249947 | 15:89,172,601 | C/T | — | uncertain significance |
| rs763291238 | 15:89,172,604 | G/A | — | likely benign |
| rs370206856 | 15:89,172,632 | T/C | — | uncertain significance |
| rs949567235 | 15:89,173,373 | C/G | — | uncertain significance |
| rs112681816 | 15:89,173,382 | C/G | — | uncertain significance |
| rs150568865 | 15:89,173,386 | G/C | — | uncertain significance |
| rs374980015 | 15:89,173,451 | G/T | — | uncertain significance |
| rs369014614 | 15:89,173,480 | C/A | — | likely benign |
| rs776271669 | 15:89,173,481 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.