AFAP1L2
actin filament associated protein 1 like 2
Summary
Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants73 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1179696556 | 10:116,055,811 | C/T | — | uncertain significance |
| rs201700224 | 10:116,056,775 | C/T | — | likely benign |
| rs750404595 | 10:116,056,780 | G/A | — | uncertain significance |
| rs1440853692 | 10:116,056,795 | T/C | — | uncertain significance |
| rs889313487 | 10:116,056,829 | C/A | — | uncertain significance |
| rs140286473 | 10:116,057,000 | G/A | — | likely benign |
| rs141490574 | 10:116,057,002 | G/T | — | uncertain significance |
| rs747793424 | 10:116,057,017 | T/C | — | uncertain significance |
| rs2495363480 | 10:116,057,034 | G/A | — | uncertain significance |
| rs1589899072 | 10:116,057,048 | C/G | — | uncertain significance |
| rs745981925 | 10:116,057,049 | T/C | — | uncertain significance |
| rs115650575 | 10:116,057,096 | G/A | — | likely benign |
| rs201900085 | 10:116,057,098 | G/A | — | uncertain significance |
| rs11599051 | 10:116,057,110 | C/T | — | uncertain significance |
| rs372048907 | 10:116,057,116 | G/A | — | uncertain significance |
| rs148977860 | 10:116,057,125 | C/T | — | uncertain significance |
| rs1330460245 | 10:116,057,148 | T/C | — | uncertain significance |
| rs752318393 | 10:116,057,157 | G/A | — | uncertain significance |
| rs200106844 | 10:116,059,967 | C/T | — | uncertain significance |
| rs144048981 | 10:116,060,005 | G/C | — | likely benign |
| rs760017215 | 10:116,060,073 | C/T | — | uncertain significance |
| rs749239862 | 10:116,060,115 | C/T | — | uncertain significance |
| rs376841532 | 10:116,060,310 | G/C | — | uncertain significance |
| rs977002229 | 10:116,060,314 | G/A | — | uncertain significance |
| rs150906523 | 10:116,060,337 | C/T | — | uncertain significance |
| rs139384712 | 10:116,060,365 | C/T | — | uncertain significance |
| rs62641716 | 10:116,060,402 | C/T | — | benign |
| rs748556898 | 10:116,060,406 | T/G | — | uncertain significance |
| rs759115083 | 10:116,061,162 | C/T | — | uncertain significance |
| rs752359432 | 10:116,061,163 | G/A | — | uncertain significance |
| rs2495863898 | 10:116,061,168 | T/A | — | uncertain significance |
| rs762524421 | 10:116,061,174 | G/A | — | uncertain significance |
| rs148826444 | 10:116,061,209 | C/A | — | uncertain significance |
| rs540007841 | 10:116,062,141 | C/T | — | uncertain significance |
| rs370972134 | 10:116,062,231 | C/T | — | uncertain significance |
| rs142000900 | 10:116,064,556 | C/A | — | uncertain significance |
| rs759285640 | 10:116,064,567 | C/T | — | uncertain significance |
| rs781022952 | 10:116,064,606 | G/A | — | uncertain significance |
| rs887113324 | 10:116,067,573 | C/T | — | uncertain significance |
| rs781509933 | 10:116,067,580 | C/T | — | likely benign |
| rs1484105226 | 10:116,067,626 | A/T | — | uncertain significance |
| rs760251651 | 10:116,067,631 | G/T | — | uncertain significance |
| rs768064098 | 10:116,068,201 | T/C | — | uncertain significance |
| rs2042753215 | 10:116,068,269 | A/G | — | uncertain significance |
| rs144885661 | 10:116,068,273 | C/T | — | uncertain significance |
| rs149120116 | 10:116,070,129 | C/T | — | uncertain significance |
| rs996842756 | 10:116,070,165 | G/A | — | uncertain significance |
| rs771347071 | 10:116,073,691 | A/G | — | uncertain significance |
| rs778065011 | 10:116,075,393 | C/T | — | uncertain significance |
| rs147328544 | 10:116,075,401 | C/T | — | uncertain significance |
| rs369203123 | 10:116,075,402 | G/A | — | uncertain significance |
| rs139300071 | 10:116,075,405 | C/T | — | uncertain significance |
| rs267602372 | 10:116,075,441 | G/A | — | uncertain significance |
| rs768531018 | 10:116,075,442 | C/A | — | uncertain significance |
| rs143236926 | 10:116,075,456 | C/T | — | uncertain significance |
| rs766066704 | 10:116,075,474 | C/T | — | likely benign |
| rs199977219 | 10:116,075,477 | C/T | — | uncertain significance |
| rs1860082 | 10:116,077,998 | A/T | intron variant | — |
| rs2498114271 | 10:116,082,944 | T/C | — | uncertain significance |
| rs1385396847 | 10:116,082,954 | C/T | — | uncertain significance |
| rs755610281 | 10:116,083,010 | C/T | — | uncertain significance |
| rs2498958869 | 10:116,091,585 | G/C | — | uncertain significance |
| rs2498960509 | 10:116,091,600 | G/A | — | uncertain significance |
| rs1273770131 | 10:116,092,983 | T/C | — | uncertain significance |
| rs776641266 | 10:116,093,022 | C/T | — | uncertain significance |
| rs2499059857 | 10:116,093,044 | C/G | — | uncertain significance |
| rs745638107 | 10:116,100,382 | C/T | — | uncertain significance |
| rs140378605 | 10:116,100,383 | G/A | — | uncertain significance |
| rs200998583 | 10:116,100,395 | C/T | — | uncertain significance |
| rs36110313 | 10:116,122,103 | T/C | — | — |
| rs1106475 | 10:116,123,035 | C/T | intron variant | — |
| rs646668 | 10:116,138,034 | G/A | intron variant | — |
| rs4751674 | 10:116,139,029 | T/C | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.