AGMO
alkylglycerol monooxygenase
Summary
The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]
Known Variants82 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs769593390 | 7:15,240,920 | G/C | — | uncertain significance |
| rs1389508255 | 7:15,240,941 | A/G | — | uncertain significance |
| rs147333692 | 7:15,240,972 | T/C | — | uncertain significance |
| rs569426691 | 7:15,306,444 | T/A | — | — |
| rs12531027 | 7:15,335,936 | T/C | intron variant | — |
| rs757590655 | 7:15,405,144 | A/C | — | uncertain significance |
| rs772864412 | 7:15,405,168 | G/T | — | uncertain significance |
| rs190327309 | 7:15,405,178 | G/A | — | likely benign |
| rs76463825 | 7:15,405,181 | A/C | — | benign |
| rs181773805 | 7:15,405,188 | C/T | — | likely benign |
| rs139309795 | 7:15,405,189 | G/A | — | conflicting classifications of pathogenicity |
| rs201588410 | 7:15,405,215 | C/T | — | uncertain significance |
| rs80328842 | 7:15,405,219 | G/C | — | benign |
| rs549433708 | 7:15,405,221 | G/C | — | likely benign |
| rs1782970276 | 7:15,405,775 | G/C | — | uncertain significance |
| rs145243646 | 7:15,405,785 | A/C | — | uncertain significance |
| rs771969222 | 7:15,405,806 | A/C | — | uncertain significance |
| rs1242741647 | 7:15,405,826 | G/A | — | uncertain significance |
| rs67615620 | 7:15,421,023 | T/C | intron variant | — |
| rs199707904 | 7:15,425,061 | T/C | — | likely benign |
| rs747012970 | 7:15,425,091 | C/T | — | uncertain significance |
| rs144084616 | 7:15,425,096 | T/C | — | uncertain significance |
| rs375360314 | 7:15,425,124 | C/T | — | uncertain significance |
| rs771391281 | 7:15,425,133 | A/G | — | uncertain significance |
| rs139340804 | 7:15,425,134 | T/C | — | likely benign |
| rs146651080 | 7:15,425,136 | T/G | — | uncertain significance |
| rs140207104 | 7:15,425,168 | G/A | — | uncertain significance |
| rs2534633693 | 7:15,425,175 | C/A | — | uncertain significance |
| rs201562437 | 7:15,425,181 | C/T | — | uncertain significance |
| rs1427748045 | 7:15,427,051 | G/C | — | uncertain significance |
| rs751893917 | 7:15,427,083 | G/A | — | uncertain significance |
| rs1783962073 | 7:15,427,084 | G/A | — | uncertain significance |
| rs191099541 | 7:15,427,137 | G/A | — | benign |
| rs759396968 | 7:15,427,145 | T/C | — | uncertain significance |
| rs560020764 | 7:15,427,147 | T/C | — | uncertain significance |
| rs59160822 | 7:15,427,149 | G/T | — | benign |
| rs765665400 | 7:15,430,303 | T/C | — | likely benign |
| rs144104404 | 7:15,430,328 | G/A | — | uncertain significance |
| rs139972453 | 7:15,430,495 | C/A | — | uncertain significance |
| rs143439626 | 7:15,430,506 | T/C | — | uncertain significance |
| rs148836202 | 7:15,430,521 | C/T | — | uncertain significance |
| rs2534659456 | 7:15,430,525 | T/C | — | uncertain significance |
| rs150962030 | 7:15,433,761 | G/A | — | uncertain significance |
| rs1402147323 | 7:15,433,771 | G/C | — | uncertain significance |
| rs142034204 | 7:15,433,777 | G/C | — | uncertain significance |
| rs748990108 | 7:15,433,792 | G/A | — | uncertain significance |
| rs565738776 | 7:15,433,793 | G/C | — | uncertain significance |
| rs368244667 | 7:15,433,804 | C/G | — | uncertain significance |
| rs73284431 | 7:15,434,230 | G/C | intron variant | — |
| rs28635514 | 7:15,458,186 | T/C | — | benign |
| rs146442781 | 7:15,458,194 | T/A | — | benign |
| rs754148955 | 7:15,458,200 | A/T | — | uncertain significance |
| rs773104971 | 7:15,458,245 | G/C | — | uncertain significance |
| rs773227617 | 7:15,458,253 | A/C | — | uncertain significance |
| rs1177367994 | 7:15,458,263 | G/C | — | uncertain significance |
| rs758015123 | 7:15,458,273 | G/A | — | likely benign |
| rs2534794411 | 7:15,470,661 | C/T | — | uncertain significance |
| rs1211709458 | 7:15,470,668 | C/T | — | uncertain significance |
| rs779870725 | 7:15,470,677 | A/T | — | uncertain significance |
| rs116358801 | 7:15,470,714 | G/A | — | benign |
| rs2534794756 | 7:15,470,727 | T/C | — | uncertain significance |
| rs7781293 | 7:15,490,983 | C/T | — | — |
| rs4628172 | 7:15,495,150 | T/G | intron variant | — |
| rs55905169 | 7:15,506,529 | G/A | — | — |
| rs7789097 | 7:15,508,136 | C/A | intron variant | — |
| rs149570873 | 7:15,584,409 | G/A | — | uncertain significance |
| rs917375519 | 7:15,584,417 | C/T | — | uncertain significance |
| rs1784731872 | 7:15,584,475 | A/C | — | uncertain significance |
| rs1026744158 | 7:15,584,483 | T/C | — | likely benign |
| rs766074394 | 7:15,584,487 | A/G | — | uncertain significance |
| rs148330185 | 7:15,599,767 | T/C | — | uncertain significance |
| rs373631505 | 7:15,599,775 | C/T | — | uncertain significance |
| rs144754984 | 7:15,599,820 | C/T | — | uncertain significance |
| rs2535174862 | 7:15,599,857 | C/G | — | uncertain significance |
| rs370958429 | 7:15,599,875 | A/T | — | uncertain significance |
| rs769378096 | 7:15,599,877 | G/T | — | uncertain significance |
| rs981047599 | 7:15,601,368 | C/G | — | uncertain significance |
| rs143371620 | 7:15,601,379 | T/C | — | conflicting classifications of pathogenicity |
| rs750988147 | 7:15,601,388 | G/A | — | uncertain significance |
| rs367804914 | 7:15,601,401 | T/C | — | uncertain significance |
| rs61751889 | 7:15,601,445 | T/A | — | benign |
| rs61751892 | 7:15,601,449 | G/C | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.