AGO3
argonaute RISC catalytic component 3
Summary
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2524040352 | 1:36,411,309 | G/C | — | uncertain significance |
| rs188633282 | 1:36,432,651 | A/G | — | uncertain significance |
| rs1447928281 | 1:36,432,662 | G/A | — | uncertain significance |
| rs766091679 | 1:36,437,703 | G/T | — | uncertain significance |
| rs370300022 | 1:36,437,741 | G/C | — | likely benign |
| rs1571451383 | 1:36,437,747 | G/A | — | likely benign |
| rs755264603 | 1:36,437,751 | G/A | — | uncertain significance |
| rs140942553 | 1:36,437,822 | G/A | — | benign |
| rs147480778 | 1:36,439,027 | C/T | — | likely benign |
| rs143581788 | 1:36,439,076 | C/T | — | uncertain significance |
| rs1640244300 | 1:36,469,956 | T/C | — | uncertain significance |
| rs1569732554 | 1:36,469,967 | A/G | — | likely benign |
| rs753247568 | 1:36,474,546 | G/A | — | likely benign |
| rs144067198 | 1:36,474,588 | G/A | — | likely benign |
| rs74645199 | 1:36,474,618 | A/G | — | benign |
| rs2524314617 | 1:36,474,629 | C/T | — | uncertain significance |
| rs2148814635 | 1:36,475,122 | A/G | — | uncertain significance |
| rs201835772 | 1:36,479,252 | A/G | — | uncertain significance |
| rs149225833 | 1:36,479,268 | A/G | — | uncertain significance |
| rs41267265 | 1:36,479,290 | G/A | — | likely benign |
| rs1044077164 | 1:36,479,338 | C/G | — | likely benign |
| rs767090774 | 1:36,479,520 | G/A | — | uncertain significance |
| rs2524349740 | 1:36,479,600 | G/T | — | uncertain significance |
| rs147063309 | 1:36,479,642 | A/G | — | uncertain significance |
| rs761567226 | 1:36,492,735 | G/A | — | uncertain significance |
| rs2148833931 | 1:36,492,783 | T/C | — | uncertain significance |
| rs138501451 | 1:36,492,880 | G/A | — | benign |
| rs143959736 | 1:36,499,843 | A/G | — | benign |
| rs769738476 | 1:36,499,921 | G/C | — | uncertain significance |
| rs1352979263 | 1:36,499,944 | G/A | — | likely benign |
| rs139849193 | 1:36,501,799 | A/G | — | likely benign |
| rs151098893 | 1:36,501,817 | C/T | — | likely benign |
| rs149864052 | 1:36,501,829 | T/C | — | likely benign |
| rs143283288 | 1:36,505,507 | A/G | — | benign |
| rs368356934 | 1:36,505,997 | G/A | — | likely benign |
| rs1642194476 | 1:36,506,010 | A/T | — | uncertain significance |
| rs145947091 | 1:36,509,116 | C/T | — | likely benign |
| rs1374660526 | 1:36,520,593 | G/C | — | uncertain significance |
| rs79043007 | 1:36,520,615 | G/A | — | benign |
| rs376625988 | 1:36,521,283 | A/G | — | likely benign |
| rs61743816 | 1:36,521,340 | C/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.