AGRP
agouti related neuropeptide
Summary
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Known Variants14 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs201485380 | 16:67,516,547 | G/A | — | uncertain significance |
| rs750837166 | 16:67,516,561 | A/T | — | uncertain significance |
| rs769073853 | 16:67,516,580 | G/A | — | uncertain significance |
| rs34730014 | 16:67,516,605 | G/C | — | benign |
| rs2041512150 | 16:67,516,643 | C/T | — | uncertain significance |
| rs768146316 | 16:67,516,652 | C/T | — | uncertain significance |
| rs145840661 | 16:67,516,674 | T/C | — | uncertain significance |
| rs5030980 | 16:67,516,945 | C/T | missense variant | pathogenic |
| rs528111571 | 16:67,516,964 | T/G | — | uncertain significance |
| rs370523045 | 16:67,517,002 | G/A | — | uncertain significance |
| rs11575892 | 16:67,517,055 | G/A | upstream gene variant | — |
| rs34123523 | 16:67,517,179 | C/T | synonymous variant | benign |
| rs898112158 | 16:67,517,233 | C/T | — | uncertain significance |
| rs745643706 | 16:67,517,288 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.