ALG10
ALG10 alpha-1,2-glucosyltransferase
Summary
This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1488967375 | 12:34,175,569 | C/A | — | uncertain significance |
| rs199684664 | 12:34,175,585 | T/G | — | uncertain significance |
| rs781587193 | 12:34,175,638 | A/G | — | uncertain significance |
| rs537406273 | 12:34,176,942 | A/G | — | likely benign |
| rs367638429 | 12:34,176,955 | A/G | — | uncertain significance |
| rs774843037 | 12:34,176,976 | G/C | — | uncertain significance |
| rs199743090 | 12:34,176,993 | G/T | — | uncertain significance |
| rs760859547 | 12:34,176,997 | G/A | — | uncertain significance |
| rs754158100 | 12:34,177,003 | T/A | — | uncertain significance |
| rs2497896035 | 12:34,177,015 | G/A | — | uncertain significance |
| rs56393741 | 12:34,177,079 | A/G | — | likely benign |
| rs759631487 | 12:34,178,801 | G/A | — | uncertain significance |
| rs1942826274 | 12:34,178,829 | C/T | — | uncertain significance |
| rs77450248 | 12:34,178,830 | A/C | — | benign |
| rs764838672 | 12:34,178,873 | C/G | — | uncertain significance |
| rs752156373 | 12:34,178,971 | T/G | — | uncertain significance |
| rs199700179 | 12:34,178,985 | G/A | — | uncertain significance |
| rs780471031 | 12:34,179,008 | G/C | — | uncertain significance |
| rs759341957 | 12:34,179,039 | A/G | — | uncertain significance |
| rs372903050 | 12:34,179,045 | C/T | — | uncertain significance |
| rs1466933872 | 12:34,179,110 | G/C | — | uncertain significance |
| rs78273253 | 12:34,179,157 | C/T | — | benign |
| rs185875444 | 12:34,179,233 | G/A | — | benign |
| rs772916617 | 12:34,179,273 | A/C | — | uncertain significance |
| rs367613863 | 12:34,179,456 | C/G | — | uncertain significance |
| rs553709023 | 12:34,179,470 | C/A | — | uncertain significance |
| rs534786683 | 12:34,179,495 | T/C | — | uncertain significance |
| rs1942835433 | 12:34,179,504 | G/C | — | uncertain significance |
| rs370166956 | 12:34,179,529 | A/T | — | uncertain significance |
| rs1236865938 | 12:34,179,558 | A/G | — | uncertain significance |
| rs750715253 | 12:34,179,562 | A/G | — | uncertain significance |
| rs762214045 | 12:34,179,674 | C/T | — | uncertain significance |
| rs201276321 | 12:34,179,675 | G/A | — | uncertain significance |
| rs754034632 | 12:34,179,716 | C/A | — | uncertain significance |
| rs1312892222 | 12:34,179,753 | G/A | — | uncertain significance |
| rs121908850 | 12:34,179,767 | G/A | missense variant | benign |
| rs1377334596 | 12:34,179,794 | C/T | — | likely benign |
| rs370615064 | 12:34,179,816 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.