ALKBH3
alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
Summary
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Known Variants19 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1385747578 | 11:43,904,245 | G/A | — | uncertain significance |
| rs769872970 | 11:43,904,684 | G/T | — | uncertain significance |
| rs554790465 | 11:43,904,700 | C/T | — | uncertain significance |
| rs762849148 | 11:43,905,558 | G/A | — | uncertain significance |
| rs1012291927 | 11:43,905,564 | T/C | — | uncertain significance |
| rs561931169 | 11:43,908,161 | A/G | — | uncertain significance |
| rs774464321 | 11:43,911,315 | G/A | — | uncertain significance |
| rs745969101 | 11:43,913,620 | G/T | — | uncertain significance |
| rs768997072 | 11:43,913,641 | T/C | — | uncertain significance |
| rs765666915 | 11:43,913,664 | G/A | — | uncertain significance |
| rs1022104992 | 11:43,923,066 | T/G | — | uncertain significance |
| rs950628754 | 11:43,923,087 | C/G | — | uncertain significance |
| rs764403690 | 11:43,923,095 | C/A | — | uncertain significance |
| rs1240676119 | 11:43,923,099 | A/G | — | uncertain significance |
| rs1554977122 | 11:43,923,115 | G/A | — | uncertain significance |
| rs372711510 | 11:43,923,151 | G/T | — | uncertain significance |
| rs762082312 | 11:43,923,154 | A/G | — | uncertain significance |
| rs10838202 | 11:43,939,764 | C/T | — | — |
| rs144890252 | 11:43,940,618 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.