ALPK2

alpha kinase 2

Summary

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Acts upstream of or within regulation of gene expression. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants2,384 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3744867	18:56,149,048	A/G	—	benign
rs1268669620	18:56,149,061	T/A	—	uncertain significance
rs2051312784	18:56,149,067	T/A	—	uncertain significance
rs2051312795	18:56,149,068	T/G	—	uncertain significance
rs543965909	18:56,149,069	C/T	—	uncertain significance
rs149246242	18:56,149,070	G/T	—	likely benign
rs2144089644	18:56,149,076	G/A	—	likely benign
rs2518842533	18:56,149,077	G/A	—	uncertain significance
rs779696708	18:56,149,081	C/G	—	uncertain significance
rs371027763	18:56,149,082	A/G	—	likely benign
rs2518842541	18:56,149,084	G/A	—	likely benign
rs530988474	18:56,149,085	C/T	—	likely benign
rs2518842547	18:56,149,087	C/G	—	uncertain significance
rs2518842548	18:56,149,089	G/T	—	uncertain significance
rs2083937108	18:56,149,090	C/T	—	likely benign
rs772084467	18:56,149,094	C/G	—	uncertain significance
rs773170762	18:56,149,096	T/C	—	uncertain significance
rs1568061859	18:56,149,098	A/G	—	uncertain significance
rs7240666	18:56,149,099	T/C	—	benign
rs138028987	18:56,149,100	T/C	—	likely benign
rs201143538	18:56,149,101	G/C	—	uncertain significance
rs1349600514	18:56,149,103	C/T	—	uncertain significance
rs143495285	18:56,149,105	T/C	—	uncertain significance
rs1348146324	18:56,149,107	G/T	—	uncertain significance
rs1271318747	18:56,149,108	A/G	—	uncertain significance
rs61743671	18:56,149,109	G/C	—	uncertain significance
rs751594533	18:56,149,111	T/G	—	uncertain significance
rs2518842603	18:56,149,113	G/A	—	uncertain significance
rs532674203	18:56,149,115	T/C	—	likely benign
rs2518842613	18:56,149,120	C/G	—	uncertain significance
rs767948648	18:56,149,123	T/C	—	uncertain significance
rs2518842615	18:56,149,124	G/A	—	likely benign
rs750802597	18:56,149,125	C/A	—	uncertain significance
rs2518842619	18:56,149,127	T/C	—	likely benign
rs546545381	18:56,149,133	A/G	—	likely benign
rs2518842625	18:56,149,137	C/T	—	uncertain significance
rs749006100	18:56,149,139	C/T	—	likely benign
rs35196844	18:56,149,140	G/T	—	uncertain significance
rs2518842633	18:56,149,141	G/A	—	uncertain significance
rs1252583565	18:56,149,142	C/T	—	likely benign
rs2518842636	18:56,149,144	G/C	—	uncertain significance
rs2518842641	18:56,149,148	C/T	—	likely benign
rs2518842654	18:56,149,155	T/C	—	uncertain significance
rs375278224	18:56,149,157	G/T	—	uncertain significance
rs2518842663	18:56,149,159	T/G	—	uncertain significance
rs2518842668	18:56,149,161	T/C	—	uncertain significance
rs1424954803	18:56,149,163	G/A	—	likely benign
rs1406302807	18:56,149,171	G/A	—	uncertain significance
rs773223876	18:56,149,174	A/G	—	uncertain significance
rs2518842687	18:56,149,179	A/G	—	uncertain significance
rs2518842691	18:56,149,181	T/C	—	likely benign
rs753325716	18:56,149,182	C/G	—	uncertain significance
rs2051313788	18:56,149,184	C/G	—	likely benign
rs2518842701	18:56,149,185	A/G	—	uncertain significance
rs2051313806	18:56,149,188	A/G	—	uncertain significance
rs536026243	18:56,149,193	G/A	—	likely benign
rs2518842719	18:56,149,194	C/G	—	uncertain significance
rs2518842727	18:56,149,200	T/C	—	uncertain significance
rs2051313859	18:56,149,201	T/G	—	uncertain significance
rs2518842733	18:56,149,202	G/A	—	likely benign
rs2051313873	18:56,149,204	T/C	—	uncertain significance
rs2518842735	18:56,149,207	A/T	—	uncertain significance
rs763258504	18:56,149,213	G/A	—	uncertain significance
rs368005415	18:56,149,216	G/C	—	uncertain significance
rs2518842750	18:56,149,217	T/C	—	likely benign
rs2518842752	18:56,149,218	G/A	—	uncertain significance
rs1602178531	18:56,149,221	T/C	—	uncertain significance
rs2051314030	18:56,149,226	C/T	—	likely benign
rs1252630637	18:56,149,231	C/G	—	uncertain significance
rs200409620	18:56,149,232	A/G	—	likely benign
rs150798338	18:56,149,233	A/G	—	uncertain significance
rs756543711	18:56,149,234	T/G	—	uncertain significance
rs2518842772	18:56,149,235	G/T	—	uncertain significance
rs2518842778	18:56,149,240	T/C	—	uncertain significance
rs61738810	18:56,149,245	G/A	—	uncertain significance
rs777388356	18:56,149,253	G/C	—	likely benign
rs746992315	18:56,149,254	C/T	—	uncertain significance
rs1568061954	18:56,149,255	C/T	—	uncertain significance
rs776524912	18:56,149,264	C/T	—	uncertain significance
rs200719522	18:56,149,265	C/G	—	uncertain significance
rs2518842807	18:56,149,267	T/C	—	uncertain significance
rs2518851751	18:56,165,286	A/T	—	likely benign
rs2518851757	18:56,165,288	C/T	—	uncertain significance
rs748413910	18:56,165,291	G/A	—	likely benign
rs772229824	18:56,165,292	C/T	—	likely benign
rs773311555	18:56,165,293	G/A	—	uncertain significance
rs149775332	18:56,165,294	T/C	—	uncertain significance
rs2518851766	18:56,165,295	T/C	—	likely benign
rs2518851768	18:56,165,296	G/T	—	uncertain significance
rs2518851770	18:56,165,297	C/T	—	uncertain significance
rs2051410216	18:56,165,299	A/G	—	uncertain significance
rs777060616	18:56,165,305	A/G	—	uncertain significance
rs146778283	18:56,165,307	G/C	—	uncertain significance
rs753063224	18:56,165,308	T/C	—	uncertain significance
rs1441858142	18:56,165,310	A/G	—	likely benign
rs2518851803	18:56,165,325	T/C	—	likely benign
rs2518851808	18:56,165,329	C/A	—	uncertain significance
rs1466503153	18:56,171,167	C/T	—	uncertain significance
rs776752041	18:56,171,168	A/G	—	uncertain significance
rs776002589	18:56,171,173	C/T	—	likely benign

Showing 100 of 2,384 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.