AMD1
adenosylmethionine decarboxylase 1
Summary
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]
Known Variants7 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2796749 | 6:111,194,703 | C/A | — | — |
| rs2536395684 | 6:111,208,772 | A/C | — | uncertain significance |
| rs1785856065 | 6:111,210,116 | C/A | — | uncertain significance |
| rs779004856 | 6:111,210,151 | C/A | — | uncertain significance |
| rs562875601 | 6:111,211,533 | T/C | — | uncertain significance |
| rs146968037 | 6:111,214,117 | C/T | — | uncertain significance |
| rs763764381 | 6:111,214,734 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.