ANAPC15

anaphase promoting complex subunit 15

Summary

Involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic cell cycle spindle assembly checkpoint. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants9 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs137853185	11:71,817,140	G/A	missense variant	pathogenic
rs137853186	11:71,817,211	T/C	missense variant	pathogenic
rs137853187	11:71,817,226	G/A	missense variant	pathogenic
rs137853188	11:71,817,231	C/G	stop gained	pathogenic
rs545947177	11:71,817,260	A/C	splice region variant	pathogenic
rs147594350	11:71,821,225	C/G	—	uncertain significance
rs750635497	11:71,821,239	T/A	—	likely benign
rs1486565526	11:71,821,609	A/G	—	uncertain significance
rs567093261	11:71,824,500	C/G	—	—

Gene information from NCBI Gene. Variant classifications from ClinVar.