ANAPC4
anaphase promoting complex subunit 4
Summary
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Known Variants32 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs572628404 | 4:25,377,777 | A/C | — | — |
| rs374830999 | 4:25,384,901 | C/T | — | uncertain significance |
| rs147243013 | 4:25,384,955 | C/T | — | uncertain significance |
| rs1722181576 | 4:25,390,474 | A/G | — | uncertain significance |
| rs2474837568 | 4:25,392,612 | G/A | — | uncertain significance |
| rs773529954 | 4:25,392,632 | T/A | — | uncertain significance |
| rs766016624 | 4:25,394,002 | C/T | — | uncertain significance |
| rs371711389 | 4:25,394,003 | G/A | — | uncertain significance |
| rs2474842508 | 4:25,395,445 | A/T | — | uncertain significance |
| rs757091654 | 4:25,396,482 | C/T | — | uncertain significance |
| rs781057647 | 4:25,396,491 | C/A | — | uncertain significance |
| rs148354654 | 4:25,398,369 | A/G | — | uncertain significance |
| rs368232198 | 4:25,398,479 | C/T | — | uncertain significance |
| rs16877106 | 4:25,403,266 | C/T | intron variant | — |
| rs1487038233 | 4:25,404,594 | G/A | — | uncertain significance |
| rs2474863063 | 4:25,407,239 | A/G | — | uncertain significance |
| rs570649808 | 4:25,408,503 | A/G | — | uncertain significance |
| rs1723301499 | 4:25,408,844 | G/A | — | uncertain significance |
| rs2474871175 | 4:25,411,385 | C/G | — | uncertain significance |
| rs140699299 | 4:25,415,333 | A/G | — | uncertain significance |
| rs573056698 | 4:25,416,102 | G/T | — | uncertain significance |
| rs1296491893 | 4:25,416,312 | G/C | — | uncertain significance |
| rs201954140 | 4:25,417,135 | A/G | — | uncertain significance |
| rs753903477 | 4:25,417,137 | G/A | — | uncertain significance |
| rs3816587 | 4:25,417,244 | C/T | intron variant | — |
| rs749197099 | 4:25,418,121 | G/A | — | uncertain significance |
| rs766411258 | 4:25,419,269 | C/T | — | uncertain significance |
| rs755782244 | 4:25,419,798 | G/T | — | uncertain significance |
| rs772204215 | 4:25,419,866 | G/T | — | uncertain significance |
| rs1723989966 | 4:25,419,875 | T/A | — | uncertain significance |
| rs775248115 | 4:25,419,907 | C/T | — | uncertain significance |
| rs146675413 | 4:25,419,930 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.