ANGPT4
angiopoietin 4
Summary
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]
Known Variants34 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs758172223 | 20:853,620 | G/A | — | uncertain significance |
| rs371864935 | 20:853,704 | C/T | — | likely benign |
| rs532951868 | 20:853,722 | C/T | — | likely benign |
| rs375636235 | 20:853,726 | G/T | — | uncertain significance |
| rs62641668 | 20:854,973 | T/G | — | benign |
| rs762894257 | 20:855,016 | C/T | — | uncertain significance |
| rs760416354 | 20:855,035 | C/T | — | uncertain significance |
| rs1981250723 | 20:858,894 | G/C | — | uncertain significance |
| rs746445808 | 20:860,425 | C/T | — | uncertain significance |
| rs374341010 | 20:860,443 | G/A | — | uncertain significance |
| rs754954928 | 20:860,454 | G/C | — | uncertain significance |
| rs1383333606 | 20:861,822 | G/A | — | uncertain significance |
| rs201715387 | 20:861,840 | C/T | — | uncertain significance |
| rs551030827 | 20:861,929 | G/T | — | uncertain significance |
| rs1426019461 | 20:865,745 | C/T | — | uncertain significance |
| rs760252535 | 20:865,766 | A/C | — | likely benign |
| rs781438375 | 20:865,826 | C/T | — | uncertain significance |
| rs538984668 | 20:865,844 | C/G | — | uncertain significance |
| rs371525435 | 20:865,879 | G/C | — | uncertain significance |
| rs138501858 | 20:865,908 | G/C | — | uncertain significance |
| rs891025270 | 20:865,930 | T/A | — | uncertain significance |
| rs773591730 | 20:869,024 | T/C | — | uncertain significance |
| rs149811020 | 20:869,033 | A/C | — | benign |
| rs1041399657 | 20:870,947 | T/C | — | uncertain significance |
| rs79320190 | 20:870,970 | C/T | — | benign |
| rs2514293615 | 20:870,971 | T/C | — | uncertain significance |
| rs142196008 | 20:870,992 | G/A | — | likely benign |
| rs2144151 | 20:883,644 | T/C | — | — |
| rs377149306 | 20:896,565 | G/A | — | uncertain significance |
| rs1982921365 | 20:896,626 | G/A | — | uncertain significance |
| rs772883230 | 20:896,737 | C/T | — | uncertain significance |
| rs776299477 | 20:896,749 | C/G | — | uncertain significance |
| rs1433585310 | 20:896,758 | C/T | — | uncertain significance |
| rs372508631 | 20:896,821 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.