ANKZF1

ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1

Summary

Enables RNA endonuclease activity and catalytic activity, acting on a tRNA. Involved in cellular response to hydrogen peroxide; protein quality control for misfolded or incompletely synthesized proteins; and rescue of stalled ribosome. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants468 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs773173310	2:220,094,980	A/G	—	uncertain significance
rs368799905	2:220,094,985	G/A	—	likely benign
rs529485262	2:220,094,988	G/C	—	likely benign
rs2544903308	2:220,094,989	G/T	—	uncertain significance
rs763856445	2:220,094,993	C/T	—	uncertain significance
rs767131449	2:220,095,010	C/T	—	uncertain significance
rs2544903542	2:220,095,020	T/A	—	uncertain significance
rs2544903635	2:220,095,030	T/G	—	uncertain significance
rs2544903647	2:220,095,033	C/T	—	likely benign
rs1245279610	2:220,095,037	A/G	—	uncertain significance
rs2544903684	2:220,095,038	G/A	—	uncertain significance
rs372243770	2:220,095,049	C/G	—	uncertain significance
rs1264200140	2:220,095,050	C/T	—	uncertain significance
rs1307253731	2:220,095,052	G/A	—	conflicting classifications of pathogenicity
rs201539288	2:220,095,058	C/G	—	likely benign
rs2106453887	2:220,095,062	G/T	—	uncertain significance
rs193179046	2:220,095,064	C/T	—	likely benign
rs2544903941	2:220,095,073	G/C	—	uncertain significance
rs1298382006	2:220,095,102	C/T	—	likely benign
rs1308671007	2:220,095,103	C/G	—	uncertain significance
rs761175747	2:220,095,104	G/C	—	uncertain significance
rs767129944	2:220,095,118	T/G	—	uncertain significance
rs373425242	2:220,095,127	G/A	—	uncertain significance
rs1553563489	2:220,095,130	A/G	—	uncertain significance
rs1443991323	2:220,095,134	T/G	—	likely benign
rs532986576	2:220,095,138	A/T	—	likely benign
rs79013471	2:220,096,122	C/A	upstream gene variant	—
rs763549438	2:220,096,630	A/G	—	uncertain significance
rs376871053	2:220,096,634	C/T	—	likely benign
rs370759069	2:220,096,653	C/T	—	uncertain significance
rs2544911035	2:220,096,654	A/G	—	likely benign
rs2106458016	2:220,096,655	G/A	—	uncertain significance
rs767793054	2:220,096,658	G/A	—	uncertain significance
rs750608980	2:220,096,660	G/C	—	uncertain significance
rs2544911096	2:220,096,662	G/A	—	uncertain significance
rs369043900	2:220,096,674	A/C	—	likely benign
rs13007650	2:220,096,678	A/C	—	benign
rs188688032	2:220,096,681	G/A	—	benign
rs2544911277	2:220,096,694	C/T	—	uncertain significance
rs1304529179	2:220,096,695	C/G	—	uncertain significance
rs2106458142	2:220,096,705	T/C	—	likely benign
rs1226332415	2:220,096,708	A/G	—	likely benign
rs2544911420	2:220,096,722	G/C	—	uncertain significance
rs1341454832	2:220,096,737	A/G	—	uncertain significance
rs775071287	2:220,096,747	G/A	—	likely benign
rs2544911520	2:220,096,748	A/G	—	uncertain significance
rs2544911528	2:220,096,749	A/C	—	uncertain significance
rs1452557412	2:220,096,756	A/C	—	uncertain significance
rs200470547	2:220,096,757	G/A	—	likely benign
rs1371688732	2:220,096,762	G/A	—	uncertain significance
rs2544911633	2:220,096,766	A/G	—	uncertain significance
rs769262165	2:220,096,767	T/A	—	uncertain significance
rs2544911706	2:220,096,780	G/A	—	likely benign
rs1951063720	2:220,096,989	A/G	—	uncertain significance
rs576619621	2:220,096,991	T/C	—	uncertain significance
rs1380582732	2:220,096,992	A/G	—	uncertain significance
rs764832677	2:220,097,009	C/T	—	uncertain significance
rs776690007	2:220,097,026	A/G	—	likely benign
rs576741102	2:220,097,027	C/T	—	uncertain significance
rs2106458853	2:220,097,030	C/G	—	uncertain significance
rs2544912772	2:220,097,040	A/G	—	uncertain significance
rs779792670	2:220,097,045	C/G	—	uncertain significance
rs754609259	2:220,097,050	G/C	—	likely benign
rs200147041	2:220,097,052	C/T	—	uncertain significance
rs778316061	2:220,097,054	G/T	—	uncertain significance
rs747589774	2:220,097,058	T/C	—	uncertain significance
rs772627468	2:220,097,062	C/A	—	uncertain significance
rs747415610	2:220,097,065	T/G	—	uncertain significance
rs367763893	2:220,097,099	G/T	—	likely benign
rs191253543	2:220,097,100	G/C	—	likely benign
rs2544913859	2:220,097,200	G/T	—	likely benign
rs2106459294	2:220,097,202	C/T	—	likely benign
rs746189242	2:220,097,206	C/T	—	likely benign
rs199508320	2:220,097,212	G/C	—	uncertain significance
rs368406046	2:220,097,222	C/T	—	likely benign
rs768829938	2:220,097,230	C/T	—	uncertain significance
rs372550492	2:220,097,231	G/A	—	likely benign
rs1951073426	2:220,097,239	A/G	—	uncertain significance
rs2544914229	2:220,097,247	G/T	—	uncertain significance
rs1255934563	2:220,097,250	T/C	—	uncertain significance
rs61747682	2:220,097,257	G/C	—	benign
rs752324972	2:220,097,261	G/C	—	uncertain significance
rs1221807505	2:220,097,264	G/C	—	uncertain significance
rs757997113	2:220,097,265	G/A	—	uncertain significance
rs372463215	2:220,097,271	C/G	—	uncertain significance
rs1190447123	2:220,097,276	A/C	—	likely benign
rs922198930	2:220,097,279	G/A	—	likely benign
rs199733184	2:220,097,283	C/T	—	uncertain significance
rs202012817	2:220,097,284	G/A	—	conflicting classifications of pathogenicity
rs200506719	2:220,097,286	G/A	—	benign
rs2106459561	2:220,097,291	G/A	—	likely benign
rs376176664	2:220,097,294	T/C	—	likely benign
rs149382949	2:220,097,301	G/A	—	uncertain significance
rs1230825800	2:220,097,313	C/T	—	uncertain significance
rs373389031	2:220,097,314	G/A	—	conflicting classifications of pathogenicity
rs768958693	2:220,097,320	C/T	—	uncertain significance
rs748200374	2:220,097,332	C/T	—	uncertain significance
rs2106459695	2:220,097,334	C/T	—	uncertain significance
rs370400955	2:220,097,337	C/T	—	uncertain significance
rs776602507	2:220,097,338	G/A	—	uncertain significance

Showing 100 of 468 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.