AP1AR
adaptor related protein complex 1 associated regulatory protein
Summary
Enables AP-1 adaptor complex binding activity and kinesin binding activity. Involved in negative regulation of receptor recycling and vesicle targeting, trans-Golgi to endosome. Acts upstream of or within negative regulation of substrate adhesion-dependent cell spreading. Located in Golgi apparatus and transport vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants15 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs543058773 | 4:113,153,275 | T/C | — | uncertain significance |
| rs376272770 | 4:113,153,276 | T/G | — | uncertain significance |
| rs900441049 | 4:113,153,287 | C/G | — | uncertain significance |
| rs1473897672 | 4:113,153,300 | G/A | — | uncertain significance |
| rs773576366 | 4:113,153,309 | A/G | — | uncertain significance |
| rs1429408931 | 4:113,181,971 | T/C | — | uncertain significance |
| rs201026911 | 4:113,181,980 | G/A | — | uncertain significance |
| rs777017712 | 4:113,181,993 | A/G | — | uncertain significance |
| rs2477193980 | 4:113,181,994 | T/A | — | uncertain significance |
| rs776891284 | 4:113,184,181 | A/C | — | uncertain significance |
| rs766729050 | 4:113,184,229 | G/A | — | uncertain significance |
| rs139300460 | 4:113,187,818 | A/G | — | uncertain significance |
| rs145829842 | 4:113,189,482 | G/A | — | uncertain significance |
| rs35163370 | 4:113,189,508 | A/G | — | benign |
| rs1726799795 | 4:113,189,545 | A/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.