APOBEC2
apolipoprotein B mRNA editing enzyme catalytic subunit 2
Summary
Enables cytidine deaminase activity and identical protein binding activity. Involved in positive regulation of gene expression via chromosomal CpG island demethylation. Acts upstream of or within cytidine to uridine editing. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants16 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs770753227 | 6:41,021,091 | C/A | — | uncertain significance |
| rs1184773398 | 6:41,021,109 | C/T | — | uncertain significance |
| rs775096529 | 6:41,021,120 | G/A | — | uncertain significance |
| rs140446569 | 6:41,026,122 | C/T | regulatory region variant | — |
| rs202202906 | 6:41,029,071 | C/T | — | uncertain significance |
| rs139783430 | 6:41,029,085 | C/G | — | uncertain significance |
| rs1581991093 | 6:41,029,194 | C/T | — | uncertain significance |
| rs1241781034 | 6:41,029,233 | G/A | — | uncertain significance |
| rs773387831 | 6:41,029,281 | C/T | — | uncertain significance |
| rs549324782 | 6:41,029,298 | G/C | — | uncertain significance |
| rs746120000 | 6:41,029,440 | C/G | — | uncertain significance |
| rs114127156 | 6:41,029,530 | T/C | — | benign |
| rs1762881519 | 6:41,029,543 | A/G | — | uncertain significance |
| rs2532530944 | 6:41,029,557 | A/G | — | likely benign |
| rs374264492 | 6:41,029,578 | T/A | — | uncertain significance |
| rs150558136 | 6:41,029,581 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.