APOBEC3G
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
Summary
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene catalyzes site-specific deamination of both RNA and single-stranded DNA. The encoded protein has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity. [provided by RefSeq, Mar 2017]
Known Variants23 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs5757463 | 22:39,472,565 | G/T | — | — |
| rs757889503 | 22:39,474,955 | G/A | — | uncertain significance |
| rs368187496 | 22:39,475,007 | C/T | — | uncertain significance |
| rs967653451 | 22:39,476,965 | G/A | — | uncertain significance |
| rs1168923239 | 22:39,476,972 | G/A | — | uncertain significance |
| rs138285438 | 22:39,476,980 | C/G | — | uncertain significance |
| rs1368964728 | 22:39,476,990 | G/C | — | uncertain significance |
| rs144674196 | 22:39,477,130 | C/T | — | uncertain significance |
| rs6001417 | 22:39,477,377 | C/G | regulatory region variant | — |
| rs8177832 | 22:39,477,566 | A/C | missense variant | — |
| rs367576342 | 22:39,479,743 | A/G | — | uncertain significance |
| rs766997850 | 22:39,482,346 | T/G | — | uncertain significance |
| rs776436131 | 22:39,482,362 | G/T | — | uncertain significance |
| rs1437045887 | 22:39,482,366 | T/C | — | uncertain significance |
| rs918473281 | 22:39,482,392 | T/G | — | uncertain significance |
| rs746521588 | 22:39,482,442 | C/A | — | uncertain significance |
| rs1391807732 | 22:39,482,483 | C/T | — | uncertain significance |
| rs542681958 | 22:39,482,486 | G/A | — | uncertain significance |
| rs375494335 | 22:39,482,524 | C/T | — | uncertain significance |
| rs150838967 | 22:39,482,546 | C/A | — | uncertain significance |
| rs374686174 | 22:39,483,055 | G/T | — | uncertain significance |
| rs144179214 | 22:39,483,097 | A/G | — | uncertain significance |
| rs35228531 | 22:39,483,844 | C/T | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.